Toward systemic lipofuscin removal

Michael Renteln

doi:10.20944/preprints202208.0229.v9

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preprints.org > biology and life sciences > aging > doi: 10.20944/preprints202208.0229.v9

Preprint Concept Paper Version 9 Preserved in Portico This version is not peer-reviewed

Toward systemic lipofuscin removal

Michael Renteln

Version 1 : Received: 11 August 2022 / Approved: 12 August 2022 / Online: 12 August 2022 (08:05:09 CEST)
Version 2 : Received: 20 September 2022 / Approved: 21 September 2022 / Online: 21 September 2022 (03:36:55 CEST)
Version 3 : Received: 26 September 2022 / Approved: 27 September 2022 / Online: 27 September 2022 (04:20:31 CEST)
Version 4 : Received: 27 October 2022 / Approved: 28 October 2022 / Online: 28 October 2022 (05:21:13 CEST)
Version 5 : Received: 2 November 2022 / Approved: 2 November 2022 / Online: 2 November 2022 (03:41:32 CET)
Version 6 : Received: 19 March 2023 / Approved: 20 March 2023 / Online: 20 March 2023 (03:43:19 CET)
Version 7 : Received: 6 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (03:36:15 CEST)
Version 8 : Received: 4 April 2024 / Approved: 5 April 2024 / Online: 8 April 2024 (13:40:34 CEST)
Version 9 : Received: 9 May 2024 / Approved: 9 May 2024 / Online: 10 May 2024 (00:49:36 CEST)

How to cite: Renteln, M. Toward systemic lipofuscin removal. Preprints 2022, 2022080229. https://doi.org/10.20944/preprints202208.0229.v9 Renteln, M. Toward systemic lipofuscin removal. Preprints 2022, 2022080229. https://doi.org/10.20944/preprints202208.0229.v9

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MDPI and ACS Style

Renteln, M. Toward systemic lipofuscin removal. Preprints 2022, 2022080229. https://doi.org/10.20944/preprints202208.0229.v9

APA Style

Renteln, M. (2024). Toward systemic lipofuscin removal. Preprints. https://doi.org/10.20944/preprints202208.0229.v9

Chicago/Turabian Style

Renteln, M. 2024 "Toward systemic lipofuscin removal" Preprints. https://doi.org/10.20944/preprints202208.0229.v9

Abstract

Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of post-mitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is the main or at least a major driving factor in aging. They even posited that the evolution of memory is the reason why we get lipofuscin at all, as stable synaptic connections must be maintained over time, meaning that the somas of neurons must also remain in the same locale. In other words, they cannot dilute out their garbage over time through cell division. Mechanistically, their position certainly makes sense given that rendering a large percentage of a post-mitotic cell’s lysosomes useless must almost certainly negatively affect that cell and the surrounding microenvironment. It may be the case that lipofuscin accumulation is the main issue with regard to current age-related disease. Degradation in situ may be an insurmountable task currently. However, a method of systemic lipofuscin removal is discussed herein.

Keywords

anti-aging; lipofuscin; Hydra vulgaris; TFEB; secretory autophagy; tissue-resident macrophages

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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