Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Approach

Version 1 : Received: 25 August 2022 / Approved: 26 August 2022 / Online: 26 August 2022 (04:36:13 CEST)

A peer-reviewed article of this Preprint also exists.

Hanna, M., Perrot, S. & Varrassi, G. Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Analgesia: A Narrative Review. Pain Ther 12, 377–398 (2023). https://doi.org/10.1007/s40122-023-00479-0 Hanna, M., Perrot, S. & Varrassi, G. Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Analgesia: A Narrative Review. Pain Ther 12, 377–398 (2023). https://doi.org/10.1007/s40122-023-00479-0

Abstract

Acute low back pain (LBP) stands as a leading cause of activity limitation and work absenteeism, and its associated healthcare expenditures are expected to become substantial when acute LBP develops into a chronic and even refractory condition. Therefore, early intervention is crucial to prevent progression to chronic pain whose management is particularly challenging and for which the most effective pharmacological therapy is still controversial. Current guideline treatment recommendations vary and are mostly driven by expertise with opinion differing across different interventions. Thus, it is difficult to formulate evidence-based guidance when relatively few randomized clinical trials did explore the diagnosis and management of LBP while employing different selection criteria, statistical analyses, and outcome measurements. This narrative review aims to provide a critical appraisal of current acute LBP management by discussing the unmet needs and areas of improvement from bench-to-bedside and proposes multimodal analgesia as the way forward to attain an effective and prolonged pain relief and functional recovery in patients with acute LBP.

Keywords

low-back pain (LBP); guidelines; gaps; evidence-based; acute pain; analgesics; multimodal analgesia; fixed doses combination (FDC)

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

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