Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Tetrahydrofuran Motif in Marine Lipids and Terpenes
Version 1
: Received: 20 September 2022 / Approved: 21 September 2022 / Online: 21 September 2022 (10:04:09 CEST)
A peer-reviewed article of this Preprint also exists.
González-Andrés, P.; Fernández-Peña, L.; Díez-Poza, C.; Barbero, A. The Tetrahydrofuran Motif in Marine Lipids and Terpenes. Mar. Drugs 2022, 20, 642. González-Andrés, P.; Fernández-Peña, L.; Díez-Poza, C.; Barbero, A. The Tetrahydrofuran Motif in Marine Lipids and Terpenes. Mar. Drugs 2022, 20, 642.
Abstract
heterocycles are particularly common moieties within marine natural products. Specifically, tetrahydrofuranyl rings are present in a variety of compounds which present complex structures and interesting biological activities. Focusing on terpenoids, a high number of tetrahydrofuran-containing metabolites have been isolated during the last decades. They show promising biological activities, making them potential leads for novel antibiotics, antikinetoplastid drugs, amoebicidal substances or anticancer drugs. Thus, they have attracted the attention of the synthetic community, and numerous approaches to their total syntheses have appeared. Here, we offer the reader an overview of marine-derived terpenoids and related compounds, with a special focus on their isolation, structure determination, biological profiles and total syntheses.
Keywords
marine natural products; oxygen heterocycles; tetrahydrofuran; total synthesis; biological activity; terpenes; fatty acids.
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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