Preprint
Hypothesis
The Hypothetical Utilisation of Entomopoxvirus to Achieve Rejuvenation through Cyclic Expression of Yamanaka Factors
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This version is not peer-reviewed
Submitted:
06 September 2022
Posted:
26 September 2022
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Abstract
Epigenetic reprogramming using cyclic expression of Yamanaka factors has been demonstrated to rejuvenate on a systemic level in animal models with no obvious deleterious effects. Here we discuss a strategy for cyclic and systemic expression of Yamanaka factors in wild-type animals amenable for adaptation as a human therapy. This is based on the use of the little- known Amsacta moorei Entomopoxvirus vector in combination with microbubble mediated focused ultrasound-driven blood vessel permeabilization to facilitate the system-wide distribution of the virus.
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Subject: Medicine and Pharmacology - Medicine and Pharmacology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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