1. Introduction
Emerging in China in late 2019 and rapidly spreading to all parts of the world to harvest the lives of millions of people, Coronavirus Disease-19 (COVID-19) has been announced by the World Health Organization as a global pandemic [
1,
2]. High infectivity of the disease (despite hygiene measures), development of new viral strains, treatment and vaccination failure, along with high fatality in certain groups (old people and patients which chronic disorders) have created a collective crisis that strikes not only COVID-19 victims and their relatives but extends to affect the whole community [
3,
4,
5,
6]. Moreover, lockdown and social distancing measures enforced by most countries to reduce disease transmission have created a general state of loneliness and promoted the flaring of negative emotions and the development of disordered behaviors (e.g., internet addiction, dysfunctional eating, and domestic violence, etc.), especially in people with a high vulnerability [
1,
6,
7,
8,
9]. In addition, terrorizing images of the outbreak and fake information communicated by mass/social media have accelerated fear levels regarding the effects of the pandemic on home finance and availability of food and essential supplies; they also heightened psychological distress and intensified traumatic emotions in the general public [
2,
10,
11]. In this respect, many studies report higher occurrence of psychological trauma in COVID-19 survivors [
3], healthcare workers [
12], older adults (with psychiatric disorders) [
13], adolescents and young adults [
14,
15], and even children [
7].
As per Diagnostic and Statistical Manual of Mental Disorders (DSM–5-TR), posttraumatic stress disorder (PTSD) is a psychiatric disorder, which develops in individuals who are exposed to or threatened to face traumatic events (e.g., death, natural and manmade disasters, severe accidents, terrorist attacks, war/combat, rape/sexual violence, or severe injuries) [
3,
16]. PTSD can precede or exacerbate psychiatric conditions (e.g., depression and anxiety disorders, suicidality, illicit drugs use, eating disorders, and psychosis) as well as physical and behavioral indicators (e.g., chronic pain and tobacco use) [
17]. Negative alterations in cognitions and mood as well as anxiety and insomnia are reported as key bridging nodes for PTSD and psychiatric co-morbidity [
18]. Indeed, anxiety and depressive symptoms in PTSD and related psychiatric co-morbidity increase the risk of suicide-related deaths among adolescents, university students, and older adults during the COVID-19 outbreak [
19,
20,
21]. The highest rates of suicidality during COVID-19 are reported among young males, older females, as well as in people with a single marital status and history of chronic physical and psychiatric disorders [
21,
22]. Therefore, sound measurement of traumatic stress may aid supportive healthcare to ameliorate distress and premature mortality among people experiencing COVID-19 traumas.
Horowitz’s model of emotional processing following trauma postulates that individuals experiencing traumatic events alternate between the experience of intrusive thoughts and emotions in one moment and avoidance strategies in the next until their experiences get psychologically assimilated [
23]. Based on this model, Horowitz et al developed the Impact of Event Scale (IES), the most popular self-report measure of traumatic stress, as a 15-item scale to capture the frequency of intrusion and avoidance symptoms. These two symptoms were latter defined as A and B criteria of post-traumatic stress disorder (PTSD) in DSM-IV. Items of the IES are rated on a four-point scale (0= not at all, 1= rarely, 3= sometimes, and 5= often) [
24,
25]. Given that PTSD victims experience other symptoms, the IES-Revised version (IES-R) was developed by including six additional items to measure symptoms of persistent hyperarousal (e.g., irritability and exaggerated startle response). The intrusion subscale of the IES-R was supplemented with an item inquiring about flashbacks. Thus, the current IES-R comprises 22 items measured on a 5-point equal response intervals (from 0 to 4) [
26]. Unlike the IES, which focused on assessing symptoms frequency, the IES-R spots the level of distress induced by traumatic symptoms relevant to a specific traumatic event [
24,
26].
The IES-R has been applied in various cultures and languages, with different statistical methods yielding mixed reports on its dimensionality: ranging from a single- or two-factor structure to four-, five-, and six-factor structures [
24,
26,
27,
28,
29,
30,
31]. In the meantime, the diagnostic categories of the revised versions of the DSM have been expanded based on recent research to include negative alterations in mood, cognition, and reactivity in addition to the previously set criteria of intrusion, avoidance, and hyperarousal [
3,
16]. Investigations of the IES-R among Arabs residing both in the Arab world and in English-speaking countries revealed a greater number of factors than that supposed to be measured by the scale [
30,
31]. In three Saudi samples, sleep disturbance, emotional dysregulation/irritability, and numbing were evident IES-R factors, which expressed excellent internal consistency as well as strong convergent and criterion validity [
31]. Arabs live in more than 11 countries in two continents, and they express a homogenous cultural heritage. However, they tend to suppress negative emotions relative to their Western counterparts [
32,
33]. With the lack of a statistically evaluated cutoff score of the Arabic IES-R, this study fills the gap by investigating cutoff scores of the Arabic IES-R and its six subscales to maximize its usability as a culturally adapted trauma detecting measure.
4. Discussion
The COVID-19 pandemic has been extensively described as a collective trauma, which has been associated with a global increase in PTSD symptoms in different population groups [
3,
7,
12,
13,
14,
15]. Variations in PTSD symptom clusters have been revealed by different robust statistical methods [
15,
18,
29,
36], and they have been integrated in the most recent versions of the DSM [
3,
16]. In accordance, our former investigation revealed three extra factors in addition to intrusion, avoidance, and hyperarousal—the main constructs covered by the IES-R. Two items described sleep disturbance following trauma, two other items described dysphoric mood/irritability associated with the traumatic experience, and four items described the emotional numbing experience. Despite their limited number of items, these three subscales demonstrated adequate reliability and criterion validity as indicated by strong correlations with measures of distress. Indeed, traumatic symptoms are reported to predicted psychological distress, reduced resilience, disordered gaming, substance abuse, disordered eating, and reckless behaviors (e.g., suicidality) during COVID-19 [
11,
17,
37,
38]. Therefore, identification of people with possibly high scores on PTSD symptoms may have implications for the diagnosis and treatment of such a demanding condition. This study explored the cutoff scores of the Arabic version of the IES-R and its six subscales in clinical and healthy Arab subjects within the context of the COVID-19 pandemic.
ROC model indices (AUC and Youden index) revealed excellent diagnostic potential of the IES-R for distress in both samples. The capacity of the IES-R and its subscales to distinguish highly distressed individuals was remarkably higher at lower cutoffs in the healthy sample than in the clinical sample (
Table 2). This finding shows that the sensitivity of the cutoff score to a specific condition may vary as a matter of the specific nature of the subjects. Psychiatric patients express considerably higher comorbidities (both physical and mental) and greater life adversities (e.g., psychosocial, economic, familial, and educational), in addition to traumatic experiences than healthy subjects, which all heighten their emotional burden [
3,
11,
18]. Accordingly, it may not be easy to determine trauma-related distress in an innately distressed group, which may justify the higher cutoffs of the IES-R and its subscales in the clinical sample. Our findings are consistent with previous studies examining the IES-R, which suggest caution about strongly recommending a certain cut point. A cutoff of 33 provided the best diagnostic accuracy in male Vietnam veterans and a community sample with varying levels of traumatic stress symptomatology [
24]. Likewise, a cutoff of 34 detected trauma among those who survived war in the Balkans [
39]. On the other hand, men with a history of PTSD who scored 37 on the IES-R expressed significant reduction in natural killer cell activity, lymphocyte subset counts, as well as the production of interferon gamma (IFN-gamma) and interleukin-4 up to10 years past trauma. Thus, this cut point may reflect trauma high enough to suppress immune functioning [
40], which is evident among psychiatric patients [
8,
9,
11,
41].
Obviously, numbing followed by avoidance had the lowest predictivity for distress, especially in the clinical sample. Meanwhile, hyperarousal followed by the irritability expressed stronger predictive capacity for distress than other subscales in both samples. This result is harmonious with those of a Chinese investigation, which reported centrality of exaggerated startle response and irritability in the arousal cluster as core symptoms in two network models addressing 1153 young adults and 683 adolescents during the COVID-19 outbreak [
15]. Notably, the specificity of the irritability subscale was lower in our clinical sample, denoting higher false negative cases. This may be expected in populations who inherently display chronically greater levels of distress than healthy people. Indeed, PTSD and its symptoms may evoke the rise of comorbid psychological problems [
17]. Therefore, clinical interviews may follow to identify patients who may have mood-related psychiatric conditions. The predictive capacity of intrusion and sleep disturbance was close to each other in both samples. However, the effect of intrusion was more pronounced than the effect of sleep disturbance in the healthy sample while the opposite was true for the clinical sample. Again, this may be due the evident chronic prevalence of sleep alterations (e.g., insomnia) in the psychiatric group [
18].
In a former investigation of the interaction among the six constructs of the Arabic IES-R, numbing resulted from the effects of hyperarousal and intrusion. Hyperarousal, intrusion, and numbing contributed to pandemic-related irritability. All these three factors predicted sleep disturbance in both samples. Sleep difficulties and depression/anxiety disorders have been highly reported during the pandemic. Cognitive PTSD symptoms (e.g., intrusion) are reported to induce PTSD-emotion specific components such as feelings of fear, anxiety, and sadness [
42]. Alterations in the circadian rhythm due to lifestyle changes associated with home confinement have been suggested as a key cause of sleep alterations. The later have been documented as a cause of depression/anxiety disorders during the pandemic [
43]. Our data were collected during the lockdown period in Saudi Arabia. However, in our samples the effects of sleep disturbance on irritability were non-significant (Supplementary materials:
Figure 1 and
Figure 2). As noted above, irritability considerably predicted high distress and sleep disturbance in both samples. Accordingly, our results show that various PTSD symptoms may induce dysphoric mood, which represents a considerable burden that may evoke circadian misalignment and more noxious psychiatric problems/ co-morbidities (sleep disturbance) in both healthy and diseased groups. This is in accordance with studies reporting the development of co-morbid psychiatric disorders (e.g., anxiety and depression) or the exacerbation of pre-existing psychiatric symptoms following traumatic exposure [
17,
18,
38].
This study supplements existing knowledge by examining the cutoff scores of the Arabic IES-R and its subscales in psychiatric patients and the general public. The study has many limitations, which we admit. Females were a majority, and psychiatric morbidity was self-reported indicating gender bias and a possibility of false selection of cases. Data are susceptible to selection bias as they were collected through an online survey that was conducted during the early stage of the pandemic from a single Arab country. Changes in the rates of PTSD symptoms across different waves of the pandemic have been reported e.g., PTSD rates in HCWs slightly increased following the appearance of new viral variants [
12] while slight reductions in PTSD rates were reported following COVID-19 vaccinations. Therefore, PTSD reported in this study may not reflect COVID-19 trauma during the pandemic, which has been ongoing for more than three years. Further replications of the study may yield valuable results.
Author Contributions
Conceptualization, Amira M. Ali and Abdulmajeed A. Alkhamees; Data curation, Abdulaziz Mofdy Almarwani; Formal analysis, Saeed Abdullah Al-Dossary and Abdulaziz Mofdy Almarwani; Funding acquisition, Abdulmajeed A. Alkhamees; Investigation, Abdulmajeed A. Alkhamees; Resources, Maha Atout and Rasmieh Al-Amer; Software, Saeed Abdullah Al-Dossary; Supervision, Amira M. Ali; Validation, Amira M. Ali; Writing – original draft, Maha Atout and Rasmieh Al-Amer; Writing – review & editing, Amira M. Ali.