Shaniv, D.; Bolisetty, S.; Young, T.E.; Mangum, B.; Ainsworth, S.; Elbers, L.; Schultz, P.; Cucchi, M.; de Wildt, S.N.; van der Zanden, T.M.; Caldwell, N.; Smits, A.; Allegaert, K. Neonatal Drug Formularies—A Global Scope. Children2023, 10, 848.
Shaniv, D.; Bolisetty, S.; Young, T.E.; Mangum, B.; Ainsworth, S.; Elbers, L.; Schultz, P.; Cucchi, M.; de Wildt, S.N.; van der Zanden, T.M.; Caldwell, N.; Smits, A.; Allegaert, K. Neonatal Drug Formularies—A Global Scope. Children 2023, 10, 848.
Shaniv, D.; Bolisetty, S.; Young, T.E.; Mangum, B.; Ainsworth, S.; Elbers, L.; Schultz, P.; Cucchi, M.; de Wildt, S.N.; van der Zanden, T.M.; Caldwell, N.; Smits, A.; Allegaert, K. Neonatal Drug Formularies—A Global Scope. Children2023, 10, 848.
Shaniv, D.; Bolisetty, S.; Young, T.E.; Mangum, B.; Ainsworth, S.; Elbers, L.; Schultz, P.; Cucchi, M.; de Wildt, S.N.; van der Zanden, T.M.; Caldwell, N.; Smits, A.; Allegaert, K. Neonatal Drug Formularies—A Global Scope. Children 2023, 10, 848.
Abstract
Neonatal drug information (DI) is essential for safe and effective pharmacotherapy in (pre)term neonates. Such information is usually absent from drug labels, making formularies a crucial part of the neonatal clinician’s toolbox. Several formularies exist worldwide, but they have never been fully mapped nor compared for content, structure and workflow. The objective of this review was to identify neonatal formularies, explore (dis)similarities, and raise awareness of their existence.Neonatal formularies were identified through self-acquaintance, experts and structured search. A questionnaire was sent to all identified formularies to provide details on formulary function. An original extraction tool was employed to collect DI from the formularies on the 10 most commonly used drugs in pre(term) neonates.Eight different neonatal formularies were identified worldwide (Europe, USA, Australia-New Zealand, Middle East). Six responded to the questionnaire and were compared for structure and content. Each formulary has its own workflow, monograph template and style, and update routine. Focus on certain aspects of DI also varies, as well as the type of initiative and funding.Clinicians should be aware of the various formularies available and their differences in characteristics and content to use them properly for the benefit of their patients.
Keywords
Drug information; drug database; drug formulary; neonatal; pediatric
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.