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Case Report

Piriform Fossa Injury during Calibration Tube Insertion in Laparoscopic Sleeve Gastrectomy

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19 April 2023

Posted:

19 April 2023

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Abstract
Piriform fossa and/or esophageal injuries caused by calibration tubes are relatively rare and re-main unelucidated. Herein, we report the case of a 36-year-old woman with morbid obesity, sleep apnea, and menstrual abnormalities who was scheduled to undergo laparoscopic sleeve gastrectomy (LSG). We inserted a 36-Fr Nelaton catheter made of natural rubber as a calibration tube during the surgery. However, excessive resistance was observed. We confirmed a submuco-sal layer detachment of approximately 5 cm from the left piriform fossa to the esophagus using intraoperative endoscopy. Additionally, LSG was performed using an endoscope as the guiding calibration tube. We inserted a nasogastric tube under endoscopy with a guidewire before com-pleting the surgery, hoping for a guiding effect on saliva flow. After 17 months, the patient suc-cessfully lost weight postoperatively without complaints of neck pain or discomfort during swallowing. Therefore, if the damage is limited to the submucosal layer, as in this case, conserva-tive therapy should be considered, which is similar to the concept of not requiring suture closure in endoscopic submucosal dissection. This case highlights the risk of iatrogenic injuries to the pi-riform fossa and/or esophagus during LSG and the importance of careful calibration tube inser-tion to prevent them.
Keywords: 
Subject: 
Medicine and Pharmacology  -   Surgery

1. Introduction

Bariatric metabolic surgery (BMS) is the most effective treatment for severe obesity and other obesity-related comorbidities. Laparoscopic sleeve gastrectomy (LSG), which is characterized by a simpler surgical technique than other BMSs, such as Roux-en-Y gastric bypass and sleeve gastrectomy with duodenojejunal bypass, is the most popular BMS according to the 7th IFSO Global Registry Report [1]. In Japan, the number of BMSs being performed has increased in recent years, mostly due to LSG [2], and a report on its efficacy and safety in the Japanese population has been published [3].
In LSG, a calibration tube with a diameter of >36 Fr is inserted orally to ensure the proper size of the sleeve-shaped stomach [4]. Due to the characteristic post-resection shape of the remnant stomach, patients experience unique complications post-LSG that differ from other BMSs, such as gastric torsion and flexion, uncontrollable gastroesophageal reflux disease (GERD), and leakage mainly in the region near the esophagogastric junction [5]. There have been many reports of these complications, and most surgeons who perform BMS have recognized these issues [6,7,8]. However, management of intraoperative iatrogenic piriform fossa and/or esophageal injuries caused by orogastric calibration tube insertion remains unclear; piriform fossa and/or esophageal iatrogenic injury during BMS is relatively rare but can be life-threatening if left untreated. Therefore, the risk of injury should not be underestimated.
Herein, we report the case of an iatrogenic injury of the piriform fossa caused by calibration tube insertion and the clinical management of this rare complication of LSG.

2. Case presentation

A 36-year-old woman with clinically severe obesity (height, 151.6 cm; weight, 97.3 kg; body mass index (BMI), 42.3 kg/m2 at the time of her first visit) suffering from obstructive sleep apnea syndrome (apnea–hypopnea index, 21.0 /hour) and menstrual abnormalities was referred to our hospital for LSG. We adopted a multidisciplinary approach, including pharmacotherapy for obesity-related comorbidities, physical activity, nutritional advice, and consultations with psychiatrists and psychologists, to rule out and support psychosocial problems and mental disorders, and determine eligibility for BMS. The patient underwent preoperative investigations to verify eligibility for general anesthesia and surgery, which included routine blood examinations, upper gastrointestinal endoscopy, computed tomography (CT), electrocardiogram, and respiratory function tests. No relevant findings were observed in these tests. Based on these results and discussions with our multidisciplinary team, we decided to perform a BMS.
While administering general anesthesia, the patient experienced difficulty with intubation using a regular direct laryngoscope, which led to the need for a second attempt using a video-blade laryngoscope. Then, an experienced anesthesiologist blindly inserted a 36-Fr calibration tube via the oral route; after the tip of the calibration tube was inserted at approximately 10–12 cm, unusual backward resistance was felt, and hence, the tube was not inserted further. The calibration tube was immediately removed, and intraoperative upper gastrointestinal endoscopy using carbon dioxide was performed. Endoscopy revealed a submucosal layer laceration approximately 5 cm deep from the left piriform fossa to the upper esophagus, which was considered an iatrogenic injury caused by the calibration tube (Figure 1).
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We consulted an otolaryngologist, who determined that the injury had likely not reached the mediastinum and it would be difficult to close the orifice. As the injury was limited to the submucosal layer and bleeding was not observed, we decided to continue with conservative follow-up to monitor the closure of the laceration. Circulation and respiratory status were stable; thus, we decided to continue the surgery. Sleeve gastrectomy was performed using an endoscope as a calibration tube with 6 cartridges of a 60-mm stapler. A full-layer continuous staple-line suture was performed using a nonabsorbable barbed suture. Before extubating, a 14-Fr nasogastric tube was placed using a guidewire during endoscopy. The operation time was 231 min with an estimated blood loss of 5 mL.
Antibiotics (sulbactam–ampicillin, 3 g every 8 h, up to postoperative day 3) were administered to prevent infection of oral anaerobic bacteria. On postoperative day 1, the patient complained of left neck pain, which was managed with acetaminophen as needed. Further, blood exams showed a white blood cell count (WBC) of 21,300 /μL and a C-reactive protein (CRP) level of 5.76 mg/dL, and the patient was afebrile. Fluoroscopy on postoperative day 1 revealed contrast retention in the left lateral neck, indicating submucosal leakage (Figure 2). Thus, a CT scan was performed immediately, which did not show any contrast accumulation in the left lateral neck; therefore, we believed that there was no prolonged retention of the leaked fluid. In addition, we observed a focal escalation of fatty tissue density on the left side of the neck and confirmed that there was no spread of inflammation to the mediastinum. Based on these results, we considered that the inflammatory spillover to the surrounding area due to saliva retention was minor and determined that conservative treatment could be continued. While continuing oral clear water intake, WBC count and CRP levels improved on postoperative day 3 to 13,610 /μL and 2.23 mg/dL, respectively. Fever was not observed during the study period. The pain in the left neck gradually subsided, and no pain was noted on postoperative day 3. Fluoroscopy performed on postoperative day 4 confirmed no submucosal leakage of the contrast medium (Figure 3). The nasogastric tube was removed on postoperative day 4. Finally, the patient was discharged from the hospital on postoperative day 6. The patient visited the hospital 3 days after discharge (postoperative day 9) and was confirmed to have no fever or elevated inflammatory response on blood examination. Thereafter, follow-ups were conducted according to our weight-loss program. Her weight decreased to 74.8 kg (BMI, 32.5 kg/m2, percent total weight loss, 23.1%) 17 months after the surgery, without complaints of neck pain or discomfort during swallowing.
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3. Discussion

The piriform fossa is a pharyngeal depression. Injury to this area can cause significant discomfort, and potentially lead to complications such as bleeding, infection, or even full-layer perforation.
An iatrogenic piriform fossa or esophageal injury during LSG is an uncommon complication. Typically, during LSG, a dedicated calibration tube or endoscope is inserted orally into the stomach through the pharynx and esophagus. In Japan, there is no pharmaceutically-approved calibration tube specifically designed for LSG, and intraoperative endoscopy is not always feasible. Consequently, inexpensive natural rubber catheters are often used instead of dedicated calibration tubes. In the present case, a 36-Fr Nelaton catheter was used as the calibration tube, as per usual practice. Unfortunately, the injury occurred during the procedure, which was our hospital’s first incident out of 204 procedures performed.
Although piriform fossa and/or esophageal injuries during LSG can lead to severe adverse outcomes, only a few cases regarding them have been reported [9]. We searched PubMed for studies that described perforation of the gastrointestinal tract during LSG using the keywords “bariatric surgery,” “perforation,” and “bougie,” and found six cases reported in five articles (Table 1) [10,11,12,13,14]. In all reported cases, surgical intervention, such as primary closure, patch and reinforcement with surrounding connective tissue, and placement of a drainage tube near the injured area, was required. The definitive difference between previous cases and ours is the depth of the injury. In previous reports, all cases had full-layer injuries; however, in our case, the depth of the perforation was limited to the submucosa, which is the first such case described in the literature. Hence, it was assumed that it could be treated conservatively, similar to not requiring suture closure in endoscopic submucosal dissection. Surgical interventions, such as suture reinforcement or patching, should be preferred if the perforation is deeper than the mucosal layer.
The causes of these injuries can be diverse, including anatomical abnormalities, mainly the three physiological esophageal narrowing sites (the cricopharyngeal sphincter, aortic arch, and lower esophageal sphincter), as well as factors attributable to obesity, poor calibration tube insertion technique, and the shape or rigidity of the calibration tubes. An upper gastrointestinal endoscopy was performed preoperatively to evaluate the presence of GERD, hiatal hernia, and esophageal/gastric cancer. During the preoperative endoscopy, no anatomical abnormalities were observed in the pharynx, larynx, or upper esophagus, and the endoscope was easily inserted.
The anesthesiologist in charge of this case had 4 years of experience in anesthesiology and a total of approximately 20 cases of experience in administrating anesthesia in BMS. The patient had Mallampati classification class 3 and Comack classification grade 1 and was at a relatively high risk of difficult intubation. The patient underwent esophageal intubation, which required reintubation using a video-blade laryngoscope. Patients with severe obesity are often difficult to intubate because of their short necks, small jaws, and impaired mouth openings, which may contribute to iatrogenic injuries. Furthermore, it should be noted that when the patient is intubated, the intubation tube pressurizes the pharyngeal cavity and the piriform fossa, increasing the risk of injury.
Therefore, perforation was more likely to be caused by the technique of calibration tube insertion rather than by pre-existing anatomical abnormalities. Our recommendation is to use a video-blade laryngoscope for patients in whom insertion of a calibrated tube is expected to be extremely difficult. Blind calibration tube insertion should be performed with caution as there is a potential risk of injury or perforation. Therefore, it is crucial to remain vigilant regarding these risks. In addition, we strongly advise checking the situation and attempting to reinsert the tube with the assistance of a video blade laryngoscope upon encountering excessive resistance, as in this case, to prevent or minimize any further potential damage.
In addition to the aforementioned technical concerns, the shape and rigidity of the calibration tube should be considered, and the use of a catheter specifically designed for LSG is desirable.
Currently, there are no standardized guidelines for treating iatrogenic esophageal injuries caused by calibrated tube insertion. In our case, intraoperative endoscopy using carbon dioxide showed that the cavity was easily collapsed by endoscopic insufflation; therefore, we judged that the possibility of physical retention of saliva was low and adopted a conservative treatment regimen. Moreover, we performed nasogastric tube insertion, which we believed would reduce saliva flow into the perforated dead space, functioning as a guiding tube, like a splint. Fortunately, our patient could be treated conservatively and did not develop subsequent neck abscesses or mediastinitis. However, surgical drainage, patching, and other surgical interventions are often required [10,11,12,13,14]. Patients with clinically severe obesity, who often have short, thick necks and coexisting diabetes mellitus, may have higher risks for severe neck abscesses and airway obstruction, as well as mediastinitis and mediastinal abscesses. Therefore, despite opting for conservative treatment, it is critical to monitor patient progression closely during the postoperative period.
The limitation of this study is that it is based on our single experience. We have not been able to provide evidence to assert that the submucosal injury with calibration tube insertion can be treated conservatively in all cases, as in our case. Previous reports did not mention treatment for injuries that remained in the submucosal layer; however, we believe that this report raises the possibility of considering conservative treatment depending on the severity of the injury.
The frequency of pisiform fossa and/or esophagus injuries remains unknown, highlighting the need for comprehensive multicenter surveys on these injuries in the future. We hope that such studies can provide invaluable insights into the incidence and prevalence of these injuries, as well as their underlying risk factors and potential prevention and treatment strategies.

5. Conclusions

We report the case of an intraoperative iatrogenic injury to the piriform fossa during LSG, which occurs rarely; however, given that it may lead to serious complications, the risk should not be underestimated. Although calibration tube insertion appears simple, special care should be taken because of the blinded nature of the technique; surgeons must be aware of this possibility and take necessary precautions to avoid such complications.
Conservative management is possible in selected cases; however, prompt recognition and intervention are essential to prevent serious consequences.

Supplementary Materials

None.

Author Contributions

Writing—original draft preparation, T.N.; writing—review and editing, T.O., K.W., N.K., Y.M., K.K., A.S., T.K., T.U., and Y.S.; supervision, S.O. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Ethics Committee of Toho University Sakura Medical Center (protocol code S21023, date: August 09, 2021)

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

No new data were created or analyzed in this study. Data sharing is not applicable to this article.

Acknowledgments

We would like to thank Editage (www.editage.com) for English language editing.

Conflicts of Interest

The authors declare no conflict of interest or financial ties.

References

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  2. Oshiro, T.; Kasama, K.; Nabekura, T.; Sato, Y.; Kitahara, T.; Matsunaga, R.; Arai, M.; Kadoya, K.; Nagashima, M.; Okazumi, S. Current Status and Issues Associated with Bariatric and Metabolic Surgeries in Japan. Obes. Surg. 2021, 31, 343–349. [Google Scholar] [CrossRef] [PubMed]
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  8. A Mohamed, A.; A Humaida, A.; Qureshi, A.S. Delayed Post-Laparoscopic Sleeve Gastrectomy Leak Successfully Treated With Endoscopic Clips and Tissue Adhesive: Case Report and Literature Review. Cureus 2021, 13. [Google Scholar] [CrossRef] [PubMed]
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  11. Patel, A.; Hsin, M.-C.; Huang, C.-K. Bougie-Induced Esophageal Perforation During Laparoscopic Roux-en-Y Gastric Bypass Surgery with Hiatus Hernia Repair. Obes. Surg. 2020, 30, 3249–3250. [Google Scholar] [CrossRef] [PubMed]
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  13. Signorini, F.J.; Verónica, G.; Marcos, M.; German, V.; Federico, M. Iatrogenic injury of the intrathoracic oesophagus with bougie during sleeve gastrectomy. J. Minimal Access Surg. 2018, 14, 79–82. [Google Scholar] [CrossRef] [PubMed]
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Table 1. Previous reports and our case of injuries related to calibration tube insertion.
Table 1. Previous reports and our case of injuries related to calibration tube insertion.
Author No. of cases reported Age Sex Preoperative BMI Procedure Presentation Diagnosed Injury site Treatment Hospitalized days after intervention Outcome Latest observation Abnormality of the perforated area
Tadayon SMK 1 33 F 41.5 LSG Respiratory distress and subcutaneous emphysema on the right side of the head and neck 1POD The left side of the posterior wall of the cervical esophagus Primary closure 10 Alive 3M None
Enterostomy
Patel A 1 66 F 46.7 LRYGB - intra-operative The posterior perforation at the distal esophagus Primary closure and drainage 4 Alive N/A N/A
Lovece A 1 42 F 31 LSG Chest discomfort 1POD The posterior wall of the cervical esophagus Primary closure and drainage 8 Alive N/A N/A
Signorini FJ 1 64 F 39 LSG - intra-operative Below the arch of the azygos vein Primary closure 6 Alive 2Y None
Theodorou D 2 56 F 44.5 LSG Mild discomfort and dyspnea 5POD The lower esophagus Total gastrectomy, cervical esophagostomy, and enterostomy 28 Alive N/A NA
41 F 48 LAGB Left pleuritic pain 2POD middle esophagus Total esophagectomy, cervical esophagostomy and enterostomy 18 Dead N/A NA
Our case 1 36 F 42.3 LSG - Intraoperative The left piriform fossa Conservative (nasogastric tube, antibiotics) 6 Alive 17M None
LSG, Laparoscopic Sleeve Gastrectomy; LRYGB, Laparoscopic Roux-En-Y Gastric Bypass; LAGB, Laparoscopic Adjustable Gastric Banding; POD, postoperative day.
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