Review
Version 1
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Viral Vectors Engineered for Gene Therapy
Version 1
: Received: 20 April 2023 / Approved: 21 April 2023 / Online: 21 April 2023 (08:55:15 CEST)
How to cite: Lundstrom, K. Viral Vectors Engineered for Gene Therapy. Preprints 2023, 2023040697. https://doi.org/10.20944/preprints202304.0697.v1 Lundstrom, K. Viral Vectors Engineered for Gene Therapy. Preprints 2023, 2023040697. https://doi.org/10.20944/preprints202304.0697.v1
Abstract
Gene therapy has seen major progress in recent years. Viral vectors have made a significant contribution through efficient engineering for improved delivery and safety. A large variety of indications such as cancer, cardiovascular, metabolic, hematological, neurological, muscular, ophthalmological, infectious diseases, and immunodeficiency have been targeted. Viral vectors based on adenoviruses, adeno-associated viruses, herpes simplex viruses, retroviruses including lentiviruses, alphaviruses, flaviviruses, measles viruses, rhabdoviruses, Newcastle disease virus, poxviruses, picornaviruses, reoviruses, and polyomaviruses have been used. Proof-of-concept has been demonstrated for different indications in animal models. Therapeutic efficacy has also been achieved in clinical trials. Several viral vector-based drugs have been approved for the treatment of cancer, and hematological, metabolic, and neurological diseases. Moreover, viral vector-based vaccines have been approved against COVID-19 and Ebola virus disease.
Keywords
viral vectors; gene therapy; animal models; clinical trials; drug approval
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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