Atiakshin, D.; Kostin, A.; Volodkin, A.; Nazarova, A.; Shishkina, V.; Esaulenko, D.; Buchwalow, I.; Tiemann, M.; Noda, M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals2023, 16, 817.
Atiakshin, D.; Kostin, A.; Volodkin, A.; Nazarova, A.; Shishkina, V.; Esaulenko, D.; Buchwalow, I.; Tiemann, M.; Noda, M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals 2023, 16, 817.
Atiakshin, D.; Kostin, A.; Volodkin, A.; Nazarova, A.; Shishkina, V.; Esaulenko, D.; Buchwalow, I.; Tiemann, M.; Noda, M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals2023, 16, 817.
Atiakshin, D.; Kostin, A.; Volodkin, A.; Nazarova, A.; Shishkina, V.; Esaulenko, D.; Buchwalow, I.; Tiemann, M.; Noda, M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals 2023, 16, 817.
Abstract
Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is constantly expanding giving a reason for optimism for several healthcare practitioners regarding management of multiple diseases, including socially significant ones. However, mechanisms underlying the biological effects of H2 are still being actively argued. In this review, we focus on mast cells as a potential target for H2 at the level of a specific tissue microenvironment. H2 regulates processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the state of the integrated-buffer metabolic environment and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H2 and offers great opportunities for translating the obtained findings into clinical practice.
Keywords
molecular hydrogen; reactive oxygen intermediates; mast cells; secretome; specific mast cell proteases; local tissue microenvironment; inflammation
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.