Tanabe, S.; Boonstra, E.; Hong, T.; Quader, S.; Ono, R.; Cabral, H.; Aoyagi, K.; Yokozaki, H.; Perkins, E.J.; Sasaki, H. Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer. Genes 2023, 14, 2073. https://doi.org/10.3390/genes14112073
Tanabe, S.; Boonstra, E.; Hong, T.; Quader, S.; Ono, R.; Cabral, H.; Aoyagi, K.; Yokozaki, H.; Perkins, E.J.; Sasaki, H. Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer. Genes 2023, 14, 2073. https://doi.org/10.3390/genes14112073
Tanabe, S.; Boonstra, E.; Hong, T.; Quader, S.; Ono, R.; Cabral, H.; Aoyagi, K.; Yokozaki, H.; Perkins, E.J.; Sasaki, H. Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer. Genes 2023, 14, 2073. https://doi.org/10.3390/genes14112073
Tanabe, S.; Boonstra, E.; Hong, T.; Quader, S.; Ono, R.; Cabral, H.; Aoyagi, K.; Yokozaki, H.; Perkins, E.J.; Sasaki, H. Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer. Genes 2023, 14, 2073. https://doi.org/10.3390/genes14112073
Abstract
To reveal the relationship between metallodrugs and cancer malignancy, molecular networks of anti-cancer drugs were analyzed. Molecular networks in several types of cancers were analyzed in Ingenuity Pathway Analysis (IPA). Analysis of carboplatin revealed the causal network in diffuse large B-cell lymphoma. Analysis of 12 analyses of cisplatin treatment identified causal networks including camptothecin and NUPR1. The causal network of camptothecin, which includes PTEN, FAS, and IRF1, was inactivated in diffuse-type GC and activated in intestinal-type GC. Upstream regulator analysis of cisplatin revealed an increase in FAS, BTG2, SESN1 and CDKN1A, and the involvement of the tumor microenvironment pathway. Upstream regulators of cisplatin-treated lung adenocarcinoma included a histone deacetylase inhibitor, trichostatin A (TSA). Causal network of arsenic was inactivated in diffuse-type GC and activated in intestinal-type GC, and included ERK, EGFR, SRC, IKK and TP53. Prediction of RNA-RNA interactions with the causal network of arsenic identified 10 microRNAs including mir-101, mir-103, and mir-22. The results revealed the involvement of EMT in arsenic treatment. Analysis of oxaliplatin, a platinum drug, revealed that the SPINK1 pancreatic cancer pathway is inactivated in ischemic cardiomyopathy. The study showed the importance of the relationship between platinum drugs or arsenic trioxide and the tumor microenvironment in the treatment of resistant cancer in humans.
Keywords
drug resistance; cisplatin; arsenic; tumor microenvironment; microRNA; molecular pathway network
Subject
Biology and Life Sciences, Life Sciences
Copyright:
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