Shakhpazyan, N.; Mikhaleva, L.; Bedzhanyan, A.; Gioeva, Z.; Sadykhov, N.; Mikhalev, A.; Atiakshin, D.; Buchwalow, I.; Tiemann, M.; Orekhov, A. Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets. Biomedicines 2023, 11, 2361, doi:10.3390/biomedicines11092361.
Shakhpazyan, N.; Mikhaleva, L.; Bedzhanyan, A.; Gioeva, Z.; Sadykhov, N.; Mikhalev, A.; Atiakshin, D.; Buchwalow, I.; Tiemann, M.; Orekhov, A. Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets. Biomedicines 2023, 11, 2361, doi:10.3390/biomedicines11092361.
Shakhpazyan, N.; Mikhaleva, L.; Bedzhanyan, A.; Gioeva, Z.; Sadykhov, N.; Mikhalev, A.; Atiakshin, D.; Buchwalow, I.; Tiemann, M.; Orekhov, A. Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets. Biomedicines 2023, 11, 2361, doi:10.3390/biomedicines11092361.
Shakhpazyan, N.; Mikhaleva, L.; Bedzhanyan, A.; Gioeva, Z.; Sadykhov, N.; Mikhalev, A.; Atiakshin, D.; Buchwalow, I.; Tiemann, M.; Orekhov, A. Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets. Biomedicines 2023, 11, 2361, doi:10.3390/biomedicines11092361.
Abstract
This review systematically examines the multifaceted relationship between the tumor microenvironment, stromal interactions, and colorectal cancer (CRC) progression and metastasis. The analysis begins by assessing the gut microbiome's influence on CRC development, emphasizing its association with gut-associated lymphoid tissue (GALT). The role of the Wnt signaling pathway in CRC tumor stroma is scrutinized, elucidating its impact on disease progression. Tumor budding, its effect on tumor stroma, and implications for patient prognosis are investigated. The review also identifies conserved oncogenic signatures (COS) within CRC stroma and explores their potential as therapeutic targets. Lastly, the seed and soil hypothesis is employed to contextualize metastasis, accentuating the significance of both tumor cells and the surrounding stroma in metastatic propensity. In summary, this review highlights the intricate interdependence between CRC cells and their microenvironment, providing valuable insights into prospective therapeutic approaches targeting tumor-stroma interactions.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.