Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis

Version 1 : Received: 5 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (13:14:21 CEST)

How to cite: Matasariu, D. R.; Mandici, C.-E.; Ursache, A.; Bausic, A. I. G.; Bujor, I. E.; Cristofor, A. E.; Bratila, E.; Lozneanu, L. Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis. Preprints 2023, 2023060322. https://doi.org/10.20944/preprints202306.0322.v1 Matasariu, D. R.; Mandici, C.-E.; Ursache, A.; Bausic, A. I. G.; Bujor, I. E.; Cristofor, A. E.; Bratila, E.; Lozneanu, L. Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis. Preprints 2023, 2023060322. https://doi.org/10.20944/preprints202306.0322.v1

Abstract

(1) Background: To investigate the effect of phosphohistone H3 (PHH3) and vitamin D receptor (VDR) in the risk assessment of endometriosis, in two cohorts of women with this pathology, those receiving hormonal treatment, and those without treatment; (2) Methods: In 60 cases of women with endometriosis, the paraffin-embedded endometriosis tissue samples, retrieved after surgery, were immunohistochemically (IHC) analyzed aiming to determine the expression status of PHH3 and VDR; (3) Results: The IHC positive index of PHH3 and VDR of these two groups were compared. PHH3 levels were positively correlated with vitamin D levels, both being increased in patients without treatment. Within the group without treatment, PHH3 and VDR expressions were positively associated; (4) Conclusions: IHC analysis of PHH3 and VDR can be used as an additional tool for risk stratification and prognostic assessment in patients with endometriosis.

Keywords

phosphohistone H3; vitamin D; vitamin D receptor; progesterone; endometriosis; immunohistochemistry

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

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