Version 1
: Received: 7 June 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (07:17:52 CEST)
Version 2
: Received: 11 June 2023 / Approved: 12 June 2023 / Online: 12 June 2023 (05:29:21 CEST)
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci.2023, 24, 11439.
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci. 2023, 24, 11439.
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci.2023, 24, 11439.
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci. 2023, 24, 11439.
Abstract
Management of chronic inflammation and wounds has always been a key issue in the pharmaceutical and healthcare sector. Curcumin (CCM) is an active ingredient extracted from turmeric rhizomes that has antioxidant, anti-inflammatory, and antibacterial activities, thus showing significant effectiveness toward wound healing. However, its shortcomings such as poor water solubility, poor chemical stability and fast metabolic rate limit its bioavailability and long-term use. In this context, hydrogels appear to be a versatile matrix for carrying and stabilizing drugs due to the biomimetic structure, soft porous microarchitecture, and pleasant biomechanical properties. The drug loading/releasing efficiencies can also be controlled by use of highly crystalline and porous metal organic frameworks (MOFs). Here, a flexible hydrogel composed of sodium alginate (SA) matrix and CCM-loaded MOFs was constructed for long-term drug release and antibacterial activity. The morphology and physicochemical properties of composite hydrogels were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet visible spectroscopy (UV-Vis), Raman spectroscopy and mechanical property tests. The results showed that the composite hydrogel was highly twistable and bendable to mechanically comply with human skin. The as-prepared hydrogel could capture efficient CCM for slow drug release as well as effective killing of bacteria. Therefore, such composite hydrogel is expected to provide a new management system for chronic wound dressings.
Keywords
Curcumin; MOF; Sodium Alginate Hydrogel; Drug Release; Antibacterial Activity
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
12 June 2023
Commenter:
Yingzhi Chen
Commenter's Conflict of Interests:
Author
Comment:
We have made corrections to the images, mainly to the units of the UV-Vis absorption spectra(Fig2.c) and the wavelength scans of ethanol solutions of different CCM concentrations(Fig4. a).
Commenter: Yingzhi Chen
Commenter's Conflict of Interests: Author