Review
Version 1
Preserved in Portico This version is not peer-reviewed
Clinical Applications of Polypodium leucotomos (Fernblock®): An Update
Version 1
: Received: 22 June 2023 / Approved: 23 June 2023 / Online: 23 June 2023 (08:58:58 CEST)
A peer-reviewed article of this Preprint also exists.
Rodríguez-Luna, A.; Zamarrón, A.; Juarranz, Á.; González, S. Clinical Applications of Polypodium leucotomos (Fernblock®): An Update. Life 2023, 13, 1513. Rodríguez-Luna, A.; Zamarrón, A.; Juarranz, Á.; González, S. Clinical Applications of Polypodium leucotomos (Fernblock®): An Update. Life 2023, 13, 1513.
Abstract
Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated to sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization. It has also been used to treat skin diseases such as photodermatoses, photoaggravated inflammatory conditions and pigmentary disorders. This review examines the most recent developments in the clinical application of Fernblock® and assesses how newly investigated action mechanisms may influence its clinical use.
Keywords
Polypodium leucotomos; Fernblock®; photoprotection; photodermatoses; photoaging; hyperpigmentation
Subject
Medicine and Pharmacology, Dermatology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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