Franchina, M.; Pizzimenti, C.; Fiorentino, V.; Martini, M.; Ricciardi, G.R.R.; Silvestris, N.; Ieni, A.; Tuccari, G. Low and Ultra-Low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes. International Journal of Molecular Sciences 2023, 24, 12795, doi:10.3390/ijms241612795.
Franchina, M.; Pizzimenti, C.; Fiorentino, V.; Martini, M.; Ricciardi, G.R.R.; Silvestris, N.; Ieni, A.; Tuccari, G. Low and Ultra-Low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes. International Journal of Molecular Sciences 2023, 24, 12795, doi:10.3390/ijms241612795.
Franchina, M.; Pizzimenti, C.; Fiorentino, V.; Martini, M.; Ricciardi, G.R.R.; Silvestris, N.; Ieni, A.; Tuccari, G. Low and Ultra-Low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes. International Journal of Molecular Sciences 2023, 24, 12795, doi:10.3390/ijms241612795.
Franchina, M.; Pizzimenti, C.; Fiorentino, V.; Martini, M.; Ricciardi, G.R.R.; Silvestris, N.; Ieni, A.; Tuccari, G. Low and Ultra-Low HER2 in Human Breast Cancer: An Effort to Define New Neoplastic Subtypes. International Journal of Molecular Sciences 2023, 24, 12795, doi:10.3390/ijms241612795.
Abstract
HER2-low and ultra-low breast cancer (BC) have been recently proposed as new subcategories of HER2 BC, re-considering the immunohistochemical negative score of 0, 1+ or score of 2+/in situ hybridization (ISH) negative phenotype. In the present review we have outlined the needed criteria to exactly distinguish HER2 low and ultra-low BC. Recent clinical trials have demonstrated significant clinical benefits of novel HER2 directing antibody-drug conjugates (ADCs) in treating these group sof tumors. In particular, Trastuzumab-deruxtecan (T-Dxd), a HER2-directing ADC has been recently approved by the U.S. Food and Drug Administration as the first targeted therapy to treat HER2-low BC. Furthermore, ongoing trials, such as the DESTINY-Breast06, are currently evaluating ADCs in patients with HER2-ultra low BC. Finally we hope that new guidelines may help to codify HER2 low and ultra-low BC, increasing our knowledge of tumor biology and improving a targetable new therapeutical treatment.
Medicine and Pharmacology, Pathology and Pathobiology
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