Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exploring Autophagy in Treating Spike Protein-related Pathology

Version 1 : Received: 26 June 2023 / Approved: 27 June 2023 / Online: 27 June 2023 (12:33:46 CEST)

How to cite: Halma, M. T.; Marik, P. E.; Saleeby, Y. M. Exploring Autophagy in Treating Spike Protein-related Pathology. Preprints 2023, 2023061903. https://doi.org/10.20944/preprints202306.1903.v1 Halma, M. T.; Marik, P. E.; Saleeby, Y. M. Exploring Autophagy in Treating Spike Protein-related Pathology. Preprints 2023, 2023061903. https://doi.org/10.20944/preprints202306.1903.v1

Abstract

Fasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore the therapeutic potential of fasting on spike protein-related pathology and the role of interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, and metformin. In conclusion, fasting, coupled with an understanding of its nuances, holds promise as a therapeutic intervention for spike protein related diseases; with broad implications for human health. This review presents the therapeutic possibility of using autophagy to treat spike protein related diseases, and details the interventions to deploy this therapeutic modality.

Keywords

Fasting; autophagy; long-COVID; post-vaccination syndrome; spike protein; mitochondria; mitophagy

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

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