Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fermented Rice Beverages Modulate Key Enzymes Related to Type 2 Diabetes In Vitro

Version 1 : Received: 6 July 2023 / Approved: 10 July 2023 / Online: 11 July 2023 (03:02:32 CEST)

How to cite: Otunola, G. A.; Talabi, O. T.; Oduro-Yeboah, C.; Nyako, J.; Ojo, O.; Afolayan, A. J. Fermented Rice Beverages Modulate Key Enzymes Related to Type 2 Diabetes In Vitro. Preprints 2023, 2023070617. https://doi.org/10.20944/preprints202307.0617.v1 Otunola, G. A.; Talabi, O. T.; Oduro-Yeboah, C.; Nyako, J.; Ojo, O.; Afolayan, A. J. Fermented Rice Beverages Modulate Key Enzymes Related to Type 2 Diabetes In Vitro. Preprints 2023, 2023070617. https://doi.org/10.20944/preprints202307.0617.v1

Abstract

Background: The therapeutic benefits of fermented foods in the treatment and prevention of Type 2 diabetes mellitus have been reported. Aim: Inhibitory effect of fermented rice beverages on α-amylase, α-glucosidase and pancreatic lipase was evaluated. Method: Two fermented rice beverages-fermented rice alone (FKR) and fermented rice plus roasted peanuts (FKRG) were produced using spontaneous fermentation. Capacity of the beverages to inhibit al-pha-glucosidase, alpha-amylase and pancreatic lipase in vitro was evaluated and compared with standards (positive controls). Results: FKR exerted inhibition of α-glucosidase between 9.23-21.11% and FKRG 1.11-17.36% at the various concentrations respectively, with both samples showing the most significant inhibition (about 20%) at 125 μg/mL. FKRG exhibited greater alpha-amylase inhibition activity than FKR, but for both samples, the most significant (P < 0.05) inhibition occurred at 500 μg/mL. With pancreatic lipase, no significant inhibition was observed for both FKR and FKRG at the tested concentrations compared to Orlistat used as control; how-ever, at 31.25 μg /mL FKRG showed an inhibitory effect of approximately 15%, which was not evident at higher concentrations. Conclusion: Low to moderate inhibition of α-amylase, α-glucosidase and pancreatic lipase by both FKR and FKRG, showed that the fermented rice beverages have potential to modulate hyperglycemia in type 2 diabetes in vitro. This is an indi-cation that fermented rice beverage could prevent postprandial hyperglycemia in vivo.

Keywords

Fermented beverages; type 2 diabetes; postprandial hyperglycemia; carbohydrate metabolizing enzymes; Rice

Subject

Biology and Life Sciences, Food Science and Technology

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