Almaguer, G.; Almaguer-Vargas, G.; Molina-Trinidad, E.M.; Becerril-Flores, M.A.; Montejano, B.; Madrigal-Santillan, E.; Hernández-Ceruelos, A.; Figueroa-Gutiérrez, A.H.; Montejano, E.; Montejano-Rodríguez, J.R. Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphoma. Plants2023, 12, 3757.
Almaguer, G.; Almaguer-Vargas, G.; Molina-Trinidad, E.M.; Becerril-Flores, M.A.; Montejano, B.; Madrigal-Santillan, E.; Hernández-Ceruelos, A.; Figueroa-Gutiérrez, A.H.; Montejano, E.; Montejano-Rodríguez, J.R. Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphoma. Plants 2023, 12, 3757.
Almaguer, G.; Almaguer-Vargas, G.; Molina-Trinidad, E.M.; Becerril-Flores, M.A.; Montejano, B.; Madrigal-Santillan, E.; Hernández-Ceruelos, A.; Figueroa-Gutiérrez, A.H.; Montejano, E.; Montejano-Rodríguez, J.R. Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphoma. Plants2023, 12, 3757.
Almaguer, G.; Almaguer-Vargas, G.; Molina-Trinidad, E.M.; Becerril-Flores, M.A.; Montejano, B.; Madrigal-Santillan, E.; Hernández-Ceruelos, A.; Figueroa-Gutiérrez, A.H.; Montejano, E.; Montejano-Rodríguez, J.R. Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphoma. Plants 2023, 12, 3757.
Abstract
The search for more efficacy and fewer toxic effects in cancer treatments is the main objective of research into new therapies. Vincristine (VCR) is a chemotherapeutic used in different types of tumors. Epigallocatechin gallate (EGCG) is a green tea metabolite that has shown an antineoplastic effect in different investigations, so the objective of this work was to evaluate the antitumor effect of the EGCG/VCR combination on tumor volume and survival. To achieve this objective, the solid model of lymphoma L5178Y was used in BALB/c mice with different doses of VCR, EGCG and their combination; Tumor grow and survival time were recorded. Once the tumors were obtained, they were measured and immunohistochemistry was performed for p53, Bcl2 and CD1. The results showed that the EGCG/vincristine combination had a greater antitumor effect that vincristine and EGCG. This can be partly attributed to the fact that the greatest Bcl2 inhibition was present in the combination of EGCG with vincristine. Therefore, it can be concluded that the combination of EGCG with vincristine has a better antineoplastic effect by inhibiting tumor development and increasing survival than both substances independently.
Keywords
EGCG; Cancer; Vincristine; p53; Bcl2
Subject
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
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