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Cardiac Laterality: Surgical Results of Right Atrial Isomerism

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05 September 2023

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07 September 2023

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Abstract
Right atrial isomerism (RAI) is a complex entity whose treatment and outcome are heterogeneous. The aim of this study was to analyze the results obtained after cardiac surgery in patients with RAI. A retrospective study was conducted; it included patients diagnosed with RAI who underwent cardiac surgery; their follow-up was from January 1, 2010 to March 31, 2020. Demographic characteristics and perioperative conditions were described. Thirty-eight patients with RAI were included, the median age was 4 years (IQR 2-9.2), and 57.9% were men. The main diagnoses were atrioventricular canal (63.2%) and pulmonary stenosis (55.3%). The most common surgical procedures were modified Blalock‐Taussig shunt (65.8%) and total cavopulmonary connection with an extracardiac conduit fenestrated without cardiopulmonary bypass (15.9%). The use of inhaled nitric oxide was a marker of postoperative mortality in critically ill patients (OR: 10.33; 95% CI: 1.04 - 102.08; p = 0.02). The overall survival was 86.8%, with a better outcome in those who did not require reintubation (Log Rank, p < 0.01). The survival of RAI was similar to other centers of reference. Individuals with RAI should be evaluated rigorously to determine an adequate repair strategy, considering high morbidity and mortality.
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Subject: Medicine and Pharmacology  -   Anatomy and Physiology

1. Introduction

During the embryonic growth of vertebrates, the heart is the first organ to be developed through cardiogenesis, a specialized process that involves various interactions between morphogenetic and transcriptional pathways. Any deregulation that impacts the expression of cardiac genes could affect the development of the heart and, therefore, cause cardiac malformations [1,2].
Globally, cardiac malformations in live newborns reach 0.8%. Although these malformations are probably inherited, up until now, their origin has not been exactly defined, and they are considered to be of a multifactorial cause [3].
The prevalence varies in each region, ranging from 2.1 to 12.3 per 1,000 live births [4], with an incidence of 6 to 8 per 1,000 live births worldwide [5], where atrial isomerism (AI) is one of the most serious and lest frequent forms, with a prevalence of 1 in every 10,000 to 20,000 live births worldwide [6,7].
AI is a heart malformation of the body's left-right axis, having mirror images symmetrical to each other, with normal morphology of the left-right side [3,7-9], resulting in the impossibility of establishing a normal left-right asymmetry during the embryonic development [10]. Taken into a consideration the functional relevance of organ asymmetry in humans, the heart is undoubtedly the most striking case. Not only is its location asymmetrically positioned in the thorax, but the heart is asymmetrically constructed in such a way that the left and right atriums, as well as the left and right ventricles, differ in several matters, including their pumping performance and their connection to arteries and veins [10].
Laterality problems come across with high uncertainty due to the limited knowledge and the impossibility of accurately determine the existing situation, as well as the possibility of more than one outcome. Various investigations have shown that more than 80 genes are involved in the development of normal asymmetric organs. Mutations in a few genes have been identified in patients with laterality disorders, such as Nodal and Pitx2 genes, as well as NKX2.5, CRELD1, LEFTY2, ZIC3 and CRIPTC genes, which are associated with the encoding of components involved in the transforming growth factor beta (TGF-β) pathway. When the TGF-β pathway is altered, it causes one of two entities: right atrial isomerism (RAI) or left atrial isomerism (LAI) [3, 11, 12].
RAI is typically associated with complex cardiovascular malformations [7], and given its infrequent presentation, both diagnosis and medical/surgical management involve several methods and alternatives [13-16], from a palliative surgery through univentricular physiology to a total correction surgery for biventricular repair [7,8]. The postoperative mortality is high in these patients; furthermore, it increases when risk factors present, such as valvular regurgitation and anomalous pulmonary veins connection, among others [7,8].
As far as we know, the epidemiological impact of RAI to identify determinants of increased morbidity and mortality has yet to be studied in Mexican patients. In this regard, this research represents the importance of early detection and prevention of this complex disease. Therefore, the aim of this study was to analyze the mortality and surgical outcomes of patients with RAI who underwent cardiac surgery.

2. Materials and Methods

2.1. Study Population

The study was approved by the local institutional review board (CI-006-2023) and waved the need for informed consent. We performed an observational, descriptive, and retrospective study that included patients under 18 years of age, diagnosed with RAI, who underwent cardiac surgery and were followed-up from January 1, 2010 to March 31, 2020. Patients with incomplete medical records were excluded. The variables of interest were collected from the electronic medical records and surgical notes. Demographic data, primary diagnoses, previous interventions, including cardiac surgery and cardiac catheterization, chest x-ray, echocardiographic, computed tomography and magnetic resonance imaging data were recorded. Surgical variables included date of admission, date of surgery, indication for surgery, details of the cardiac morphology, morbidity, and any complications prior to discharge.
The diagnosis of RAI was determined through the assessment of morphological features, considering a morphologically right atrium when the appendage was pyramidal, the crista terminalis was evident, and the pectineal muscles were extending towards the vestibule of the tricuspid valve in its entire parietal extension. Additionally, the bronchopulmonary morphology was assessed, where the right bronchus was more horizontal and shorter than the left bronchus, with three lobes, and the right pulmonary branch was crossing anterior and slightly inferior to it [17]. The diagnosis of RAI was supported by echocardiography, computed tomography, magnetic resonance imaging and cardiac catheterization studies.
Arterial hypotension was considered when the systolic blood pressure was below the 5th percentile according to age [18]. Vascular injury was defined as eventual vessel damage that may occur before the surgical procedure. Major bleeding was defined as a blood loss of 7 mL/kg/h or more during two or more consecutive hours in the first 12 postoperative hours, or 84 mL/kg or more during the first 24 postoperative hours, or when a surgical re-exploration was needed due to hemorrhage during the first 24 postoperative hours [19].
The follow-up of patients was held in the outpatient clinic at one, 3, 6, and 12 months after surgery; then, the follow-ups continued annually, unless an earlier follow-up was necessary. Every follow-up stage was documented, up to the last visit in March 2020. Early mortality was defined as death occurring during the first 30 days after surgery.

2.2. Statistical analysis

Descriptive statistics were performed to analyze demographic variables. To describe the categorical variables, frequencies, and percentages (%) were used, while quantitative variables were represented in median values, interquartile range (IQR), means, and standard deviations (±SD). The normality test for quantitative variables was determined using the Kolmogorov-Smirnov test. Chi-square test was used to compare proportions; however, when fewer than five observations were made, the double-ended Fisher´s exact test and Student´s t-test were applied to compare the differences between continuous variables. Patient survival was analyzed using the Kaplan-Meier method and compared by log-rank statistics. A p value < 0.05 was considered significant. The software used was SPSS version 24.0 SPSS Inc., Chicago, IL.

3. Results

3.1. Demographic characteristics

We included 38 patients with RAI; 57.9% (n=22) were men. The median age was 4 years (IQR 2-9.2), the median weight was 14.3 kg (IQR 9.8-22.1), and the mean height was 102.2 ± 29.1 cm (Table 1). Univentricular morphology was found in every patient. Dextrocardia was found in 44.7% (n=17), and 31.6% (n=12) of patients had at least one previous operation. An association with total anomalous pulmonary venous connection (TAPVC) was observed in 34.3% (n=13), all of whom presented the supracardiac variety. Stenosis in one of the pulmonary artery branches was found in 60.5% (n=23). The most frequent degree of atrioventricular valve regurgitation (Table 1) was mild found in 71% (n=27), while the severe degree was found in 5.3% (n=2).
The main diagnoses associated were atrioventricular septal defect (n=24; 63.2%) and pulmonary stenosis (n=21; 55.3%) (Table 2). During the preoperative period, 13.2% (n=5) of patients required support with inotrope use and 15.9% (n=6) required intubation; no patient presented preoperative infection.

3.2. Surgical characteristics

The main surgical procedures (Table 2) performed were modified Blalock-Taussig shunt (MBTS) (n=25; 65.8%) and total cavopulmonary connection (TCPC) with an extracardiac conduit fenestrated without cardiopulmonary bypass (n=6; 15.9%).
Twelve (31.6%) patients had at least one previous surgery. Of those, 11 (28.9%) had an MBTS, of which in 7 (18.4%) cases a new MBTS was placed, and in the other 4 (10.5%) cases a bidirectional cavopulmonary connection (BCPC) was performed. One (2.6%) case with previous BCPC underwent a TCPC with an extracardiac conduit fenestrated.
In 11 (28.9%) cases, the MBTS was associated with the repair of the TAPVC; in 1 (2.6%) case, the MBTS was associated with an atrioventricular valve replacement as well as TAPVC repair (Table 2). The univentricular repair strategy was used in all cases. Four (10.5%) patients who required emergency surgery were identified; in all of them, MBTS was performed.

3.3. Early results

Of the 38 patients included, 13.2% (n=5) died after cardiogenic shock (Figure 1). The main transoperative complications were arterial hypotension (n=13; 34.3%), cardiorespiratory arrest (n=2; 5.3%), supraventricular tachycardia (n=2; 5.3%), ventricular fibrillation (n=1, 2.6%), atrioventricular block (n=1, 2.6%), vascular injury (n=1; 2.6%) and pulmonary hypertension (n=1; 2.6%).
Fifteen (39.5%) surgeries were performed with cardiopulmonary bypass (Table 3) with a mean time of 95.4 ± 33.7 minutes; the mean aortic cross-clamp time was 53.3 ± 30.5 minutes.
The median length of stay in the pediatric intensive care unit was of 4 days (IQR 2.2-7.7), and the median of mechanical ventilation was 22 hours (IQR 10-126) (Table 3). The postoperative complications were heart failure (n=23; 60.5%), pleural effusion (n=13; 34.3%), pulmonary hypertension (mild n=2, 5.3%; moderate n=3, 7.9%), infectious processes (n=5; 13.2%), supraventricular tachycardia (n=2; 5.3%), atrioventricular block (n=1; 2.6%), major bleeding (n=2; 5.3%) and pneumothorax (n=2; 5.3%). Four (10.5%) patients required inhaled nitric oxide (iNO).
Five patients (13.2%) underwent a new surgical intervention: 2 (5.3%) cases due to major bleeding, 2 (5.3%) due to surgical site infection, and 1 (2.6%) case to takedown of BCPC. Additionally, 21.1% (n=8) of patients required cardiac catheterization after surgery: angioplasty with stent in pulmonary branches (n=2; 5.3%), placement of a stent in the fenestration of the extracardiac conduit (n=2; 5.3%), angioplasty of the MBTS (n=1; 2.6%) and closure of the main pulmonary artery (n=1; 2.6%); the last 2 (5.3%) patients did not need additional therapeutic support.

3.4. Follow-up

A postoperative follow-up of 117 ± 4.1 months was conducted. We found that age, weight, height, previous surgery, cardiopulmonary bypass time, aortic cross-clamp time, mechanical ventilation, and length of stay in the intensive care unit were not significantly different between patients who survived the surgery and those who died. The only variable related to postoperative mortality was the use of iNO in critically ill patients (OR: 10.33; p = 0.02); the rest of the surgeries conditions were not associated with death (Table 4). In addition, no single factor was associated with mortality in the multivariate analysis.
The analysis indicated an overall survival of 86.8% at 10 years of follow-up, which became constant from the 18th month after surgery (Figure 1). A better outcome was observed in patients who did not present TAPVC (Figure 2) or anomalies in the pulmonary branches (Figure 3); from the 18th month of follow-up, those without TAPVC achieved a survival of 95%, while those without anomalies in the pulmonary branches achieved a survival of 92.3%.
Finally, survival was lower (66.7%) in patients who required reintubation, when compared to those who did not (Figure 4); this difference was statistically significant (Log Rank, p < 0.01).

4. Discussion

AI is a complex entity associated with various malformations, observed in both cardiovascular and other systems [6,7,20]; in addition to being a rare condition, according to The Society of Thoracic Surgeons [21], AI represents 1.95% of surgical procedures in patients with congenital heart disease.
Patients with cardiac malformations were considered inoperable, but this has been changing in recent years. However, the treatment of heterotaxy syndrome is evidently challenging due to the low survival in the short and medium terms. Those mentioned above was confirmed in the report provided by the Hospital for Sick Children, which in a series of 91 patients with RAI who were followed up for over a 26-year period, the overall mortality was 69%; while the overall survival estimates were 71% at 1 month, 49% at 1 year and 35% at 5 years [22].
Observations in different populations of patients with RAI who underwent univentricular or biventricular repair have been relatively scarce; however, an encouraging picture has energed in recent years. For instance, the predominant form is the RAI [7,20,23-30], which in our center is found in 58.5% of patients with AI. According to with Baban et al. [23] and Alongi et al. [24], the diagnosis is always a challenge, even when we can directly visualize the atrial morphology during the surgical procedure. However, in our center the 38 patients included in this study were diagnosed in the preoperative stage with the support of auxiliary diagnostic methods. The initial evaluation in the neonatal stage is fundamental, as well as an early postnatal care [31], due to the fact that the persistence of the right umbilical vein has recently been identified in 42% of cases of AI in the fetal period, predominantly in the RAI with 73% [32], and should include the coordinated actions of different specialities, not only pediatric cardiology and pediatric cardiac surgery.
We observed TAPVC in 34.3% (n=13) of patients (Table 1), similar to what has been marked by other groups, with a survival of 95% (Figure 2), without a significant difference from those who did not present TAPVC (Log Rank, p = 0.39) [20,23,24]. Not a single patient presented obstruction of the pulmonary venous system, which is different from the observations made by Alsoufi et al. [29], as they found an obstruction in 9% of cases; this condition is considered a factor of morbidity and mortality [24,27,31], in agreement with Chen et al. (OR: 44.338, p = 0.005) [20] and Alongi et al. (HR: 4.40, p = 0.010) [24]. At this point, we must mention that is usual in RAI the presence of two morphological right atrium that, when arriving towards the spatially located left atrium (but morphologically a right atrium), results in an abnormal pulmonary venous connection, which is observed in every patient.
We agree that pulmonary venous return anomalies are the norm in patients with RAI and consequent secondary pulmonary hypertension; however, there are pulmonary alterations that go beyond pulmonary vascular alterations. The close relationship between morphological alterations in laterality and the presence of primary ciliary dyskinesia (PCD), as well as the indispensable role of ciliary function in the embryonic node for proper differentiation in left-right laterality, has led to the search for a genetic origin linking both entities [33,34]. Thus, Nakhle et al. [35] found that 42% of patients with congenital heart disease associated with AI have some degree of ciliary dysfunction. In a retrospective study by Kennedy et al. [34], 76% of cases presented with neonatal respiratory distress and 100% of patients older than 18 years had a history of bronchiectasis. These characteristics of ciliary motility patterns and alterations in the pulmonary vasculature in patients with RAI mean that postoperative mechanical ventilation in these patients is prolonged in up to 20% of cases [36].
On the other hand, 60.5% (n=23) of patients had some degree of stenosis in one of the pulmonary artery branches (Table 1), with a survival of 92.3% (Figure 3) and no significant difference from those who did not present it (Log Rank, p = 0.28); similarly, in the univariate analysis, we observed that stenosis was not associated with mortality (p = 0.31), which coincides with what was reported by McGovern et al., where atresia in one of the pulmonary artery branches was present in 50% of cases but it was not related to mortality in this group (p = 0.37) [37].
Thirty (78.9%) patients had some degree of valvular regurgitation, of which 2.6% (n=1) was moderate, and 5.3% (n=2) was severe. Some reports have found valvular regurgitation is a mortality factor [24,37]; in our study, this heart condition (p = 0.26) was not a determining factor for the patient's outcome. Instead, valve replacement (OR: 0.11; p < 0.01) was a protective factor, disagreeing with the observations made by other researchers [24,37].
The overall survival at 10-year follow-up reached 86.8% (Figure 1), which is higher than in other reports, ranging from 44% to 70% [8,20,23,24,29,37]. Given the wide variety of cardiac malformations in AI, choosing the best repair strategies is a real challenge; we can highlight that our group used a univentricular strategy in all the patients, where the main procedure was MBTS (n= 25; 65.8%), followed by TCPC with an extracardiac conduit fenestrated (n=6; 15.9%), and BCPC without cardiopulmonary bypass (n=3; 7.9%), similar to what was reported by Alongi et al. [24]. We must emphasize that the objective of the treatment in these patients is to reduce the volume overload in the only functional ventricle. In this way, the surgery seeks to decongest this workload progressively, and at some point, if possible, to separate the two circuits, pulmonary and systemic, going from a parallel circulation into a serial circulation. Palliative procedures are diverse and are based on the anatomical variants of this pathology; therefore, surgery can be performed to create a systemic-pulmonary shunt when there is obstruction in the pulmonary circulation or perform a pulmonary artery banding in cases of pulmonary overcirculation [38,39].
In addition to the surgical procedure, cardiac catheterization, which in our center reached 21.1%, is an important complementary method, especially for a description of the vascular anatomy; furthermore, catheterization improves the physiological response of the pulmonary vasculature in older individuals with a structural heart disease, and in cases of suspected obstruction related to the pulmonary venous systems [17].
It is important to note that in our study, the use of iNO was a marker of postoperative mortality in critically ill patients (OR: 10.33; p = 0.02), a situation that has not been described by other groups [20,23,24,26-29,37]. On the other hand, when comparing the inotropic use as hemodynamic support in the different stages of the perioperative period, it was not related to the surgical success nor the survival of patients.
Instead, the absence of spleen has been considered a complementary part of the diagnosis of RAI. Recent reports indicate various varieties of spleen presentations [23,24,27,37]; finding asplenia in 68% to 79% of patients with RAI, so the predominance of infectious processes by encapsulated bacteria mainly occurs in these patients [23,27,31,37]; therefore, Bhaskar et al. (HR: 2, p = 0.008) [27] and Banka et al. (HR: 1.67, p = 0.044) [31]have considered it as a predictor of mortality. However, there were no patients with infectious processes in our center in the preoperative stage.
It is important to take into account three scenarios at the time of diagnosis: first, the predominance of RAI in patients with AI; second, despite an all-in-one diagnostic approach, a precise diagnosis is sometimes challenging, even with a direct visualization of the atrial morphology during the surgical event; and third, patients with AI, mainly RAI, show an association with other extracardiac alterations, so complementary diagnostic approaches such as abdominal ultrasonography and contrast-enhanced imaging studies at gastrointestinal level, should be considered based on the findings during the initial evaluation, in addition to the multidisciplinary work in the care of these patients [17].
This study presents the usual limitations of a retrospective, single-center, nonrandomized study. Despite gathering a complete set of variables to evaluate, there may be others we should have measured that could have changed our outcomes. Nonetheless, our cohort provides very valuable information about the health of these patients in the short and long term, not only in our medical center, but in the whole region and the whole country. This information helps to identify prognostic factors that can be modified, implemented and/or complemented with new therapeutic options.

5. Conclusions

The patients with RAI had survival similar to that of other referral centers, but they must undergo a rigorous evaluation to determine an adequate repair strategy, without ignoring the morbidity and mortality involved.
The use of iNO should be considered an important marker of mortality in critically ill patients, ruling out other factors described in the literature, such as age, anomalous pulmonary venous connection, and atrioventricular valve regurgitation.

Author Contributions

Conceptualization, D.B.O.-Z., N.P.-H., J.C.-C. and J.L.C.-S.; methodology, D.B.O.-Z., J.A.G.-M., N.P.-H. and J.M.R.-P.; software, D.B.O.-Z.; Validation, J.C.-C. and J.L.C.-S.; Formal Analysis, D.B.O.-Z.; investigation and resources, D.B.O.-Z., J.A.G.-M., J.C.-C. and J.L.C.-S.; data curation, D.B.O.-Z., N.P.-H. and J.M.R.-P.; writing – original draft preparation, D.B.O.-Z., J.A.G.-M., J.C.-C. and J.L.C.-S.; writing – review & editing, D.B.O.-Z., N.P.-H., J.M.R.-P., J.A.G.-M., J.C.-C., J.L.C.-S.; supervision, D.B.O.-Z., N.P.-H., J.C.-C. and J.L.C.-S.; project administration, D.B.O.-Z. and J.L.C.-S.; Funding acquisition, D.B.O.-Z., J.A.G.-M., J.C.-C. and J.L.C.-S. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding. The APC was funded by Instituto Nacional de Cardiología Ignacio Chávez.

Institutional Review Board Statement

The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board of Instituto Nacional de Cardiología Ignacio Chávez (protocol code: CI-006-2023 and date of approval: 20/July/2023).

Informed Consent Statement

Patient consent was waived due to study design (observational, descriptive, and retrospective).

Data Availability Statement

Data supporting results are available from the corresponding authors upon reasonable request.

Acknowledgments

Open Access funding for this article was supported by Instituto Nacional de Cardiología Ignacio Chávez. The authors are grateful to all the study participants. The authors thank Dra. Rosa Giannina Castillo-Avila for the valuable support received to improve the tables, figures, and adaptation of the information for the journal.

Conflicts of Interest

“The authors declare no conflict of interest.”

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Figure 1. Overall survival curve of patients with right atrial isomerism.
Figure 1. Overall survival curve of patients with right atrial isomerism.
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Figure 2. Kaplan–Meier curves of patients with right atrial isomerism: with and without TAPVC. TAPVC: total anomalous pulmonary venous connection.
Figure 2. Kaplan–Meier curves of patients with right atrial isomerism: with and without TAPVC. TAPVC: total anomalous pulmonary venous connection.
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Figure 3. Kaplan–Meier curves of patients with right atrial isomerism: with and without anomalies in pulmonary artery branches.
Figure 3. Kaplan–Meier curves of patients with right atrial isomerism: with and without anomalies in pulmonary artery branches.
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Figure 4. Kaplan–Meier curves of patients with right atrial isomerism: with and without reintubation.
Figure 4. Kaplan–Meier curves of patients with right atrial isomerism: with and without reintubation.
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Table 1. Overall patient with right atrial isomerism characteristics.
Table 1. Overall patient with right atrial isomerism characteristics.
Characteristics Total
n = 38
Sex, n (%)
   Male 22 (57.9)
   Female 16 (42.1)
Age (years), median (IQR) 4 (2 - 9.2)
Weight (kg), median (IQR) 14.3 (9.8 - 22.1)
Height (cm), mean (±SD) 102 (29.1)
Previous surgery, n (%)
   0 25 (65.8)
   1 12 (31.6)
   2 1 (2.6)
RACHS-1, n (%)
   2 5 (13.2)
   3 33 (86.8)
Cardiac intrathoracic position, n (%)
   Levocardia 21 (55.3)
   Dextrocardia 17 (44.7)
Atrioventricular valve regurgitation, n (%)
   None 8 (21.1)
   Mild 27 (71)
   Moderate 1 (2.6)
   Severe 2 (5.3)
Anomalous pulmonary venous connection, n (%)
   Partial 2 (5.3)
   Total 13 (34.3)
Pulmonary venous connection, n (%)
   Right atrium 15 (39.5)
   Left atrium 20 (52.6)
   Both atriums 3 (7.9)
Pulmonary artery branches, n (%)
   Normal 15 (39.5)
   Stenosis 23 (60.5)
IQR: interquartile range, RACHS-1: Risk Adjustment for Congenital Heart Surgery 1, SD: standard deviation.
Table 2. Associated defects and cardiac surgeries were performed in patients with right atrial isomerism.
Table 2. Associated defects and cardiac surgeries were performed in patients with right atrial isomerism.
Characteristic, n (%) Total
n = 38
Diagnosis
   AV canal 24 (63.2)
   Pulmonary stenosis 21 (55.3)
   PDA 17 (44.7)
   Pulmonary atresia 15 (39.5)
   TAPVC 13 (34.3)
   DORV 9 (23.7)
   Hypoplastic left ventricle 6 (15.9)
   PAPVC 2 (5.3)
Surgery
   MBTS 13 (34.3)
   MBTS + TAPVC repair 10 (26.3)
   TCPC with an extracardiac conduit fenestrated without CPB 6 (15.9)
   BCPC without CPB 3 (7.9)
   MBTS + thrombectomy of pulmonary artery + TAPVC repair 1 (2.6)
   BCPC with CPB + TAPVC repair 1 (2.6)
   BCPC with CPB + RPA angioplasty + PAPVC repair 1 (2.6)
   TCPC with an extracardiac conduit fenestrated + PAPVC repair 1 (2.6)
   Mechanical AV valve replacement + MBTS + TAPVC repair 1 (2.6)
   BCPC takedown + MBTS 1 (2.6)
AV: atrioventricular, BCPC: bidirectional cavopulmonary connection, CPB: cardiopulmonary bypass, DORV: double-outlet right ventricle, MBTS: modified Blalock-Taussig shunt, PAPVC: partial anomalous pulmonary venous connection, PDA: patent ductus arteriosus, RPA: right pulmonary artery, TAPVC: total anomalous pulmonary venous connection, TCPC: total cavopulmonary connection.
Table 3. Operative and postoperative characteristics of patients with atrial isomerism.
Table 3. Operative and postoperative characteristics of patients with atrial isomerism.
Characteristic Total
n = 38
Surgery with CPB, n (%) 15 (39.5)
CPB (min), median (IQR) 89 (67-107)
Aortic cross-clamp (min), median (IQR) 55 (22-83)
Mechanical ventilation in PICU, n (%) 34 (89.5)
Mechanical ventilation time (h); median (IQR) 22 (10-126)
Reintubation, n (%) 3 (7.9)
Days in PICU, n (%)
   < 1 day 2 (5.3)
   1 - 7 days 27 (71)
   8 - 15 days 8 (21.1)
   > 15 days 1 (2.6)
CPB: cardiopulmonary bypass, IQR: interquartile range, PICU: pediatric intensive care unit.
Table 4. Risk factors associated with mortality (univariate analysis).
Table 4. Risk factors associated with mortality (univariate analysis).
Variable OR CI 95% p
Lower Upper
Previous surgery 1.33 0.19 9.18 0.77
Anomalous pulmonary venous connection 0.81 0.65 0.97 0.08
Anomalies pulmonary artery branches 0.38 0.05 2.61 0.31
Atrioventricular valve regurgitation 0.33 0.04 2.45 0.26
Atrioventricular valve replacement 0.11 0.04 0.27 < 0.01
Preoperative intubation 4.83 0.61 38.38 0.11
Preoperative inotrope use 6.66 0.77 57.06 0.05
Transoperative inotrope use 1.19 1.02 1.39 0.25
Postoperative inotrope use 1.17 1.02 1.36 0.87
Inhaled nitric oxide use 10.33 1.04 102.08 0.02
CI: confidence interval, OR: odds ratio.
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Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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