Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Treatment of Three Ferrets Diagnosed with Ferret Systemic Coronaviral Disease Using the Nucleoside Analogue GS-441524

Version 1 : Received: 25 September 2023 / Approved: 26 September 2023 / Online: 28 September 2023 (03:19:13 CEST)

How to cite: Scaletti, F.; Puffal, J.; Neece, A. J. Treatment of Three Ferrets Diagnosed with Ferret Systemic Coronaviral Disease Using the Nucleoside Analogue GS-441524. Preprints 2023, 2023091911. https://doi.org/10.20944/preprints202309.1911.v1 Scaletti, F.; Puffal, J.; Neece, A. J. Treatment of Three Ferrets Diagnosed with Ferret Systemic Coronaviral Disease Using the Nucleoside Analogue GS-441524. Preprints 2023, 2023091911. https://doi.org/10.20944/preprints202309.1911.v1

Abstract

Ferret Systemic Coronaviral Disease (FSCD) is a systemic disease, caused by ferret systemic coronavirus, that is considered lethal in most of the ferrets that are affected by it. To our knowledge, no treatment has been shown effective against FSCD, and most of the ferrets are euthanized or die after development of clinical disease. GS-441524 has been shown effective for successfully treating cats with Feline Infectious Peritonitis (FIP), a disease that shares similarities with FSCD. However, to our knowledge treatment with GS-441524 has not been reported for treatment of FSCD in ferrets. Here we describe three cases of ferrets diagnosed with FSCD successfully cured utilizing oral GS-441524. FSCD may be effectively treated following similar protocols utilized for feline infectious peritonitis in cats

Keywords

antiviral; coronavirus; ferrets; FSCD; FIP

Subject

Medicine and Pharmacology, Veterinary Medicine

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