Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Applications Of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Version 1 : Received: 7 October 2023 / Approved: 9 October 2023 / Online: 10 October 2023 (03:25:35 CEST)

How to cite: Yavuz, B.; Mutlu, E.; Ahmed, Z.; Ben-Nissan, B.; STAMBOULIS, A. Applications Of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration. Preprints 2023, 2023100557. https://doi.org/10.20944/preprints202310.0557.v1 Yavuz, B.; Mutlu, E.; Ahmed, Z.; Ben-Nissan, B.; STAMBOULIS, A. Applications Of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration. Preprints 2023, 2023100557. https://doi.org/10.20944/preprints202310.0557.v1

Abstract

Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopedic surgery cases. This review briefly explores the involvement of EVs in tissue repair and nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-based therapies. It underscores the importance for bioengineers to comprehend and manipulate EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

Keywords

nerve regeneration; non-coding RNAs; exosome; traumatic brain injury; blood-brain barrier

Subject

Biology and Life Sciences, Other

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