Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; Lazarova, M.; Hodzhev, Y.; Grigorova, V.; Yarkov, D.; Petkova-Kirova, P. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants2023, 12, 2050.
Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; Lazarova, M.; Hodzhev, Y.; Grigorova, V.; Yarkov, D.; Petkova-Kirova, P. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants 2023, 12, 2050.
Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; Lazarova, M.; Hodzhev, Y.; Grigorova, V.; Yarkov, D.; Petkova-Kirova, P. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants2023, 12, 2050.
Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; Lazarova, M.; Hodzhev, Y.; Grigorova, V.; Yarkov, D.; Petkova-Kirova, P. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants 2023, 12, 2050.
Abstract
Alzheimer’s disease manifests itself as a complex pathological condition with neuroinflammation, oxidative stress and cholinergic dysfunction being a few of the many pathological changes. Due to the complexity of the disease current therapeutic strategies aim at a multitargeted approach often relying on a combination of sub-stances with versatile and complementary effects. In the present study, unique combination of α-lipoic acid, citicoline, extracts of leaves from olive tree and green tea, Vitamin D3, selenium and an immune supporting complex was tested in a scopolamine-induced dementia in rats. Using behavioral and biochemical methods we assessed the effects of this combination on learning and memory, and elucidated the mechanisms under-lying its effects. Our results showed that as compared to the components, experimental combination was most efficient in improving short- and long-term memory assessed by the step-through method as well as spatial memory, assessed by T-maze and Barnes maze underlying decrease in AChE activity and LPO, in-creases in SOD activity in cortex; activities of catalase and GPx, levels of BDNF and pCREB in the hippocam-pus. No significant histopathological changes or blood parameter changes were detected, making the experi-mental combination an effective and safe candidate in a multitargeted treatment of AD.
Keywords
Alzheimer’s disease; α-lipoic acid; citicoline; extract of leaves green tea; extract of leaves olive tree; vitamin D3; selenium; scopolamine
Subject
Public Health and Healthcare, Other
Copyright:
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