Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Characterization of the Disruptive Effects by two Curcuminoids, Demethoxycurcumin and Bisdemethoxycurcu-min, on the Larval Development of Drosophila melanogaster

Version 1 : Received: 23 November 2023 / Approved: 23 November 2023 / Online: 23 November 2023 (08:44:33 CET)

A peer-reviewed article of this Preprint also exists.

Jeon, J.-H.; Jeong, S.-A.; Park, D.-S.; Park, H.-H.; Shin, S.-W.; Oh, H.-W. Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster. Insects 2023, 14, 959. Jeon, J.-H.; Jeong, S.-A.; Park, D.-S.; Park, H.-H.; Shin, S.-W.; Oh, H.-W. Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster. Insects 2023, 14, 959.

Abstract

Juvenile hormones (JH) play crucial roles in insect development, reproduction, and other physi-ological functions. Because JH is specific to arthropods, including insects, it has long been stud-ied for use in pest control. Accordingly, this study aimed to identify the substances that act as JH disruptors from edible plants. Curcuminoids generally exhibit a wide range of biological ac-tivities, such as antioxidant, anti-inflammatory, antibacterial, and insecticidal properties, and they exhibit insect growth inhibitory effects. Demethoxycurcumin and bisdemethoxycurcumin, two curcuminoids from the turmeric plant Curcuma longa L. inhibit the formation of a metho-prene-tolerant (Met)–Taiman (Tai) heterodimer complex as shown through in vitro yeast two-hybrid assays. An artificial diet containing 1% (w/v) demethoxycurcumin or bisdemethox-ycurcumin reduced the number of larvae, leading to no pupal development. Building on our re-sults regarding curcuminoids, researchers can use our study as a reference to develop eco-friendly pesticides.

Keywords

Juvenile hormone; Methoprene-tolerant; diterpene; Juvenile hormone disruptor; Curcuminoids; Demethoxycurcumin; Bisdemethoxycurcumin

Subject

Biology and Life Sciences, Insect Science

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