Article
Version 2
This version is not peer-reviewed
A Method to Reverse Epimutations
Version 1
: Received: 9 December 2023 / Approved: 18 December 2023 / Online: 18 December 2023 (05:56:51 CET)
Version 2 : Received: 15 September 2024 / Approved: 15 September 2024 / Online: 17 September 2024 (05:04:16 CEST)
Version 2 : Received: 15 September 2024 / Approved: 15 September 2024 / Online: 17 September 2024 (05:04:16 CEST)
How to cite: Olsen, S. A Method to Reverse Epimutations . Preprints 2023, 2023121263. https://doi.org/10.20944/preprints202312.1263.v2 Olsen, S. A Method to Reverse Epimutations . Preprints 2023, 2023121263. https://doi.org/10.20944/preprints202312.1263.v2
Abstract
For a number of reasons, a curative treatment for most chronic diseases is still unrealized [2–4] and the incidence of many chronic diseases is rapidly increasing [5–9]. A new model is offered as a solution; that being the individualized diagnosis of homeostasis, leading to the correction of epimutations. Homeostasis diagnosis and epimutation correction, HDEC. Individuals with chronic diseases are increasingly being defined by their epimutation signatures [10,11]. Modern innovations in toxicogenomic studies are also becoming more accurate in their ability to identify the unique epigenetic signature of each toxin [12–14]. Hormesis studies (over 5,000) [15] suggest a universal principle, that a small dose is always a stimulant [16–18].These three facts present an opportunity; a method to diagnose and reverse chronic disease tendencies. This new model requires a paradigm shift in our understanding of disease origins: that dysfunctions in homeostasis [19,20] are the primary and deepest level of chronic disease causation. This is the level where the diagnosis needs to be made and where the corrections need to take place [21].
Keywords
Homeostasis; HDEC; Hormesis; Epimutations; Susceptibility; Toxicogenomics
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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