Version 1
: Received: 17 December 2023 / Approved: 18 December 2023 / Online: 19 December 2023 (05:59:36 CET)
How to cite:
FERRARI, I. V.; Patrizio, P. Promising Safety Profile of Hesperidin: A Comprehensive Toxicity Assessment among Investigated Flavonoids. Preprints2023, 2023121353. https://doi.org/10.20944/preprints202312.1353.v1
FERRARI, I. V.; Patrizio, P. Promising Safety Profile of Hesperidin: A Comprehensive Toxicity Assessment among Investigated Flavonoids. Preprints 2023, 2023121353. https://doi.org/10.20944/preprints202312.1353.v1
FERRARI, I. V.; Patrizio, P. Promising Safety Profile of Hesperidin: A Comprehensive Toxicity Assessment among Investigated Flavonoids. Preprints2023, 2023121353. https://doi.org/10.20944/preprints202312.1353.v1
APA Style
FERRARI, I. V., & Patrizio, P. (2023). Promising Safety Profile of Hesperidin: A Comprehensive Toxicity Assessment among Investigated Flavonoids. Preprints. https://doi.org/10.20944/preprints202312.1353.v1
Chicago/Turabian Style
FERRARI, I. V. and Paolo Patrizio. 2023 "Promising Safety Profile of Hesperidin: A Comprehensive Toxicity Assessment among Investigated Flavonoids" Preprints. https://doi.org/10.20944/preprints202312.1353.v1
Abstract
Abstract This study focuses on the toxicity assessment of various flavonoids, with particular emphasis on Hesperidin. Among the investigated compounds, Hesperidin exhibits notable potential and low toxicity in both short and long-term evaluations. The toxicity parameters for Hesperidin include a low Max. Tolerated Dose (Human) (0.525 log mg/kg/day), indicative of its minimal potential harm to humans. Additionally, its Oral Rat Acute Toxicity (LD50) (2.506 mol/kg) suggests a relatively low acute toxicity level. The Oral Rat Chronic Toxicity (LOAEL) (3.167 log mg/kg_bw/day) signifies a higher dose threshold for observing adverse effects over the long term. Furthermore, Hesperidin demonstrates low Minnow Toxicity (7.131 log mM), suggesting minimal impact on aquatic organisms. Overall, this comprehensive assessment positions Hesperidin as a promising flavonoid with favorable properties and minimal toxicity.
Keywords
hesperidin; flavonoids; polyphenols; pkCSM tool
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
