Luan, T.; Lin, X.; Xie, X.; Yang, G.; Wang, S.; Hao, J.; Zhou, C. First Case Report of Sunvozertinib for the Treatment of HER2 Exon 20 Insertion in Lung Adenocarcinoma. Anti-Cancer Drugs 2024, doi:10.1097/cad.0000000000001628.
Luan, T.; Lin, X.; Xie, X.; Yang, G.; Wang, S.; Hao, J.; Zhou, C. First Case Report of Sunvozertinib for the Treatment of HER2 Exon 20 Insertion in Lung Adenocarcinoma. Anti-Cancer Drugs 2024, doi:10.1097/cad.0000000000001628.
Luan, T.; Lin, X.; Xie, X.; Yang, G.; Wang, S.; Hao, J.; Zhou, C. First Case Report of Sunvozertinib for the Treatment of HER2 Exon 20 Insertion in Lung Adenocarcinoma. Anti-Cancer Drugs 2024, doi:10.1097/cad.0000000000001628.
Luan, T.; Lin, X.; Xie, X.; Yang, G.; Wang, S.; Hao, J.; Zhou, C. First Case Report of Sunvozertinib for the Treatment of HER2 Exon 20 Insertion in Lung Adenocarcinoma. Anti-Cancer Drugs 2024, doi:10.1097/cad.0000000000001628.
Abstract
Human Epidermal Growth Factor Receptor 2(HER2) is a transmembrane glycoprotein receptor with intracellular tyrosine kinase activity. It is generally considered as a poor prognostic marker. Targeted therapies, such as small molecule tyrosine kinase inhibitors (TKIs), showed limited efficacy in HER2-mutant advanced Non-Small Cell Lung Cancer (NSCLC). In the 2023 NCCN guidelines for NSCLC, Antibody-Drug Conjugate(ADC) Trastuzumab emtansine (T-DM1) is recommended for the treatment of HER2-mutant Lung Cancer (LC). However, this medication is currently not approved in certain regions.So it is necessary to explore alternative treatment options for HER2-mutant NSCLC patients.In our study of a patient with HER2 exon 20ins Lung Adenocarcinoma who had previously failed multiple TKI treatments, we discovered that Sunvozertinib could stabilize the patient's condition, achieving a progression-free survival (PFS) of 87 days. This is a novel finding that may provide new treatment options for HER2 exon 20ins patients who have failed TKI therapy.
Keywords
case report; targeted therapy; gene mutation; novel therapy
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
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