Review
Version 1
Preserved in Portico This version is not peer-reviewed
Lessons from the Thioredoxin-1 Knockout Mouse Models
Version 1
: Received: 15 January 2024 / Approved: 15 January 2024 / Online: 15 January 2024 (10:39:50 CET)
A peer-reviewed article of this Preprint also exists.
Shcholok, T.; Eftekharpour, E. Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models. Biology 2024, 13, 180. Shcholok, T.; Eftekharpour, E. Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models. Biology 2024, 13, 180.
Abstract
Redox balance is increasingly identified as a major player in cellular signaling. A fundamentally simple reaction of oxidation and reduction of cysteine residues in cellular proteins is the central concept in this complex mode of protein function regulation. Oxidation of key cysteine residues occurs at the physiological levels of reactive oxygen species (ROS) but are reduced by a supply of thiol antioxidant molecules including glutathione, glutaredoxin and thioredoxin. While these molecules show complex compensatory roles in experimental conditions, transgenic animal models provide a comprehensive picture to pinpoint the role of each antioxidant. In this review we have specifically focused on the available literature on Thioredoxin-1 system transgenic models that includes Thioredoxin and Thioredoxin reductase proteins. As identification of Thioredoxin protein targets is technically challenging the true contribution of this system in maintaining cellular balance remains unidentified, including the role of this system in the brain.
Keywords
Redox balance, thiol antioxidants, transgenic models, brain, heart, glutaredoxin, thioredoxin reductase
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment