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Version 1
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Arrhythmias and Device Therapies in Cardiac Amyloidosis
Version 1
: Received: 16 January 2024 / Approved: 17 January 2024 / Online: 17 January 2024 (15:50:03 CET)
A peer-reviewed article of this Preprint also exists.
Bukhari, S.; Khan, S.Z.; Ghoweba, M.; Khan, B.; Bashir, Z. Arrhythmias and Device Therapies in Cardiac Amyloidosis. J. Clin. Med. 2024, 13, 1300. Bukhari, S.; Khan, S.Z.; Ghoweba, M.; Khan, B.; Bashir, Z. Arrhythmias and Device Therapies in Cardiac Amyloidosis. J. Clin. Med. 2024, 13, 1300.
Abstract
Cardiac amyloidosis is caused by amyloid fibrils that deposit in the myocardial interstitium, causing restrictive cardiomyopathy and eventually death. The electromechanical, inflammatory, and autonomic changes due to amyloid deposition result in arrhythmias. Atrial fibrillation is by far the most common arrhythmia. Rate control strategy is generally poorly tolerated due to restrictive filling physiology and heart rate dependance, favoring adoption of rhythm control strategy. Anticoagulation for stroke prophylaxis is warranted irrespective of CHA2DS2Vasc score in patients with favorable bleeding profile; data on left appendage closure devices is still insufficient. Ventricular arrhythmias are also not uncommon and the role of implantable cardioverter-defibrillator in cardiac amyloidosis is controversial. There is no evidence of improvement in outcomes when used for primary prevention in these patients. Bradyarrhythmia is most commonly associated with sudden cardiac death in cardiac amyloidosis. Pacemaker implantation can help provide symptomatic relief but does not confer mortality benefit.
Keywords
Cardiac amyloidosis; arrhythmia; left atrial appendage closure device; pacemaker; implantable cardioverter-defibrillator
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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