Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

L-theanine Prolongs the Lifespan by Activating Multiple Molecular Mechanisms in UVC Exposed C. elegans

Liangwen Chen
,
Guijie Chen
ORCID logo ,
Tingting Gai
,
Xiuhong Zhou
,
Jinchi Zhu
,
Ruiyi Wang
,
Xuemei Wang
,
Yujie Guo
,
Yun Wang
* ,
Zhongwen Xie
* ORCID logo
Version 1 : Received: 5 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (12:44:31 CET)
Version 2 : Received: 2 April 2024 / Approved: 2 April 2024 / Online: 3 April 2024 (16:38:00 CEST)

A peer-reviewed article of this Preprint also exists.

Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans. Molecules 2024, 29, 2691. Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans. Molecules 2024, 29, 2691.

Abstract

L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effect, regulation of immune response, relaxing neural tension, reducing oxidative damage, etc. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) to up-regulate the expression of related genes in UVC-exposed nematodes. In addition, L-theanine treatment also up-regulated the expression of mitochondrial energy metabolism related genes in UVC-exposed nematodes. Our study provided a theoretical basis for the possibility that healthy tea drinking may prevent mitochondrial related diseases.

Keywords

UVC, mitochondrial DNA damage, C. elegans, lifespan, L-theanine

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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