Version 1
: Received: 19 March 2024 / Approved: 19 March 2024 / Online: 19 March 2024 (08:05:20 CET)
Version 2
: Received: 25 June 2024 / Approved: 26 June 2024 / Online: 26 June 2024 (13:30:55 CEST)
Version 3
: Received: 26 June 2024 / Approved: 27 June 2024 / Online: 27 June 2024 (05:01:55 CEST)
How to cite:
Srinivasan Rajsri, K.; Rao, V.; Vardhman, S. Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma. Preprints2024, 2024031092. https://doi.org/10.20944/preprints202403.1092.v3
Srinivasan Rajsri, K.; Rao, V.; Vardhman, S. Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma. Preprints 2024, 2024031092. https://doi.org/10.20944/preprints202403.1092.v3
Srinivasan Rajsri, K.; Rao, V.; Vardhman, S. Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma. Preprints2024, 2024031092. https://doi.org/10.20944/preprints202403.1092.v3
APA Style
Srinivasan Rajsri, K., Rao, V., & Vardhman, S. (2024). Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma. Preprints. https://doi.org/10.20944/preprints202403.1092.v3
Chicago/Turabian Style
Srinivasan Rajsri, K., Vaishnavi Rao and Sonaj Vardhman. 2024 "Exploring the role of HPV - from Sexually Transmitted Infection to Oropharyngeal Carcinoma" Preprints. https://doi.org/10.20944/preprints202403.1092.v3
Abstract
Human papillomavirus (HPV), a DNA virus, causes one the most common sexually transmitted infections (STI), spreading through direct sexual contact to the anogenital and oropharyngeal regions. Although most infected individuals may be asymptomatic and naturally undergo viral clearance, in some individuals HPV causes carcinogenesis of the infected epithelia. HPV now accounts for over 70% of oropharyngeal carcinomas (OPC). More than 90% of these OPC are associated with HPV 16, one of the 14 high-risk subtypes. In recent years, HPV positive (HPV+) OPC has been one of the most rapidly rising cancers, by new cancer incidence rates, especially among men. The HPV driven OPCs present some unique infection driven cellular and molecular features, constituting distinct preventive, therapeutic and prognostic strategies, in contrast to HPV negative (HPV-) OPC. In this manuscript, we drive through the role of HPV, from a sexually transmitted infection to malignancy transformation landscape, while parsing through the significant immune response environment. In this comprehensive review we collate key literature around transmission and epidemiology of HPV, while addressing the current state of clinical management, diagnosis, prevention and screening strategies, that can help shed light on this critical area.
Keywords
Human papillomavirus; Sexually transmitted infection; Oropharyngeal carcinoma; Oral cancer; Head and neck cancers
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
