Faber, D.L.; Agbarya, A.; Caspy, B.; Lapidot, M.; Rosenberg, S.K.; Schneer, S.; Sharoni, E.; Galili, R. A Single-Center Experience in Combined Oncological–Surgical Treatment for Resectable Locally Advanced Non-Small Cell Lung Cancer (NSCLC). Diseases 2024, 12, 98, doi:10.3390/diseases12050098.
Faber, D.L.; Agbarya, A.; Caspy, B.; Lapidot, M.; Rosenberg, S.K.; Schneer, S.; Sharoni, E.; Galili, R. A Single-Center Experience in Combined Oncological–Surgical Treatment for Resectable Locally Advanced Non-Small Cell Lung Cancer (NSCLC). Diseases 2024, 12, 98, doi:10.3390/diseases12050098.
Faber, D.L.; Agbarya, A.; Caspy, B.; Lapidot, M.; Rosenberg, S.K.; Schneer, S.; Sharoni, E.; Galili, R. A Single-Center Experience in Combined Oncological–Surgical Treatment for Resectable Locally Advanced Non-Small Cell Lung Cancer (NSCLC). Diseases 2024, 12, 98, doi:10.3390/diseases12050098.
Faber, D.L.; Agbarya, A.; Caspy, B.; Lapidot, M.; Rosenberg, S.K.; Schneer, S.; Sharoni, E.; Galili, R. A Single-Center Experience in Combined Oncological–Surgical Treatment for Resectable Locally Advanced Non-Small Cell Lung Cancer (NSCLC). Diseases 2024, 12, 98, doi:10.3390/diseases12050098.
Abstract
Non-Small Cell Lung Cancer (NSCLC) is the most common pulmonary malignancy, most frequently diagnosed at an advanced stage (III/IV). Patients in the Locally-Advanced Stage Subgroup (IIIA) are relatively few, yet compose of heterogenic phenotypes posing a diagnostic and treating challenge, leading to lack of clinical guidelines regarding the optimal standard of care. Several approaches exist, with a general agreement that a combined oncological and surgical modality approach is required. In this current retrospective descriptive study, operable Stage IIIA NSCLC patients who underwent surgery between 2013-2020 were evaluated on several aspects, including initial diagnosis, neoadjuvant regimens, outcomes of surgical intervention, overall survival at 2-years and 5-years following treatment. A total of 35 patients had neoadjuvant oncological treatment (mostly chemoradiation therapy) prior to surgery, out of which 28 patients were diagnosed with Stage IIIA NSCLC. In post-operative assessment of pathological staging, downstaging was reported in 20 patients, of which 7 (25%) cases were defined as complete pathological response. The 2-years overall survival rate was 65% and the 5-years overall survival rate was 60%. The main pattern of disease recurrence was distant metastasis.
Medicine and Pharmacology, Oncology and Oncogenics
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