Version 1
: Received: 24 April 2024 / Approved: 24 April 2024 / Online: 25 April 2024 (09:00:58 CEST)
Version 2
: Received: 26 April 2024 / Approved: 26 April 2024 / Online: 26 April 2024 (14:49:58 CEST)
Version 3
: Received: 9 May 2024 / Approved: 10 May 2024 / Online: 10 May 2024 (11:49:27 CEST)
Version 4
: Received: 10 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (14:33:20 CEST)
Version 5
: Received: 23 September 2024 / Approved: 24 September 2024 / Online: 24 September 2024 (10:15:22 CEST)
How to cite:
Renteln, M. Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery. Preprints2024, 2024041631. https://doi.org/10.20944/preprints202404.1631.v5
Renteln, M. Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery. Preprints 2024, 2024041631. https://doi.org/10.20944/preprints202404.1631.v5
Renteln, M. Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery. Preprints2024, 2024041631. https://doi.org/10.20944/preprints202404.1631.v5
APA Style
Renteln, M. (2024). Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery. Preprints. https://doi.org/10.20944/preprints202404.1631.v5
Chicago/Turabian Style
Renteln, M. 2024 "Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery" Preprints. https://doi.org/10.20944/preprints202404.1631.v5
Abstract
Adeno-associated viruses (AAVs) have been used for liver gene therapy.Hemgenix and Roctavian are AAV-based treatments for hemophilia B and A, respectively.They cost $3 million and $2.8 million per dose, respectively.While AAV vectors may eventually be cheaper to mass produce, a bacteria-based DNA delivery system might be much cheaper for patients.Also, “bactofection” would allow for the delivery of much larger DNA packages.Such a bacterial system may now be possible, and a prototype for the liver could possibly be developed immediately.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.