Version 1
: Received: 5 May 2024 / Approved: 6 May 2024 / Online: 6 May 2024 (12:33:49 CEST)
How to cite:
Martula, E.; Morak-Młodawska, B.; Jeleń, M.; Strzyga-Łach, P.; Struga, M.; Żurawska, K.; Kasprzycka, A. New Isomeric Dipyridothiazine Dimers — Synthesis, Structural Characterization and Cytotoxicity Screening. Preprints2024, 2024050291. https://doi.org/10.20944/preprints202405.0291.v1
Martula, E.; Morak-Młodawska, B.; Jeleń, M.; Strzyga-Łach, P.; Struga, M.; Żurawska, K.; Kasprzycka, A. New Isomeric Dipyridothiazine Dimers — Synthesis, Structural Characterization and Cytotoxicity Screening. Preprints 2024, 2024050291. https://doi.org/10.20944/preprints202405.0291.v1
Martula, E.; Morak-Młodawska, B.; Jeleń, M.; Strzyga-Łach, P.; Struga, M.; Żurawska, K.; Kasprzycka, A. New Isomeric Dipyridothiazine Dimers — Synthesis, Structural Characterization and Cytotoxicity Screening. Preprints2024, 2024050291. https://doi.org/10.20944/preprints202405.0291.v1
APA Style
Martula, E., Morak-Młodawska, B., Jeleń, M., Strzyga-Łach, P., Struga, M., Żurawska, K., & Kasprzycka, A. (2024). New Isomeric Dipyridothiazine Dimers — Synthesis, Structural Characterization and Cytotoxicity Screening. Preprints. https://doi.org/10.20944/preprints202405.0291.v1
Chicago/Turabian Style
Martula, E., Katarzyna Żurawska and Anna Kasprzycka. 2024 "New Isomeric Dipyridothiazine Dimers — Synthesis, Structural Characterization and Cytotoxicity Screening" Preprints. https://doi.org/10.20944/preprints202405.0291.v1
Abstract
New dimers of selected dipyridothiazines with an m-xylene linker have been designed, synthesized and characterized. Their structure was identified using 1H and 13C NMR as well as 2D NMR techniques (COSY, ROESY, HSQC and HMBC experiments) and HR MS spectrometry. The compounds were subjected to preliminary in silico biological profile tests using the Way2Drug server and analysis of the probable cytotoxic effect on various cancer cell lines. Preliminary in vitro cytotoxicity tests were performed against normal cell lines (HaCaT) and five cancer cell lines (SW480, SW620, MDA-MB-231, A-549, LN-229) showing moderate activity. An analysis of the structure-activity relationship was performed.
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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