Version 1
: Received: 17 May 2024 / Approved: 18 May 2024 / Online: 20 May 2024 (12:37:08 CEST)
How to cite:
Gašparová, M.; Pavílek, B.; Tisovský, P.; Ilková, S.; Tokárová, Z. Low-Field NMR as a Vital Spectral Tool in Organic Chemistry. Preprints2024, 2024051220. https://doi.org/10.20944/preprints202405.1220.v1
Gašparová, M.; Pavílek, B.; Tisovský, P.; Ilková, S.; Tokárová, Z. Low-Field NMR as a Vital Spectral Tool in Organic Chemistry. Preprints 2024, 2024051220. https://doi.org/10.20944/preprints202405.1220.v1
Gašparová, M.; Pavílek, B.; Tisovský, P.; Ilková, S.; Tokárová, Z. Low-Field NMR as a Vital Spectral Tool in Organic Chemistry. Preprints2024, 2024051220. https://doi.org/10.20944/preprints202405.1220.v1
APA Style
Gašparová, M., Pavílek, B., Tisovský, P., Ilková, S., & Tokárová, Z. (2024). Low-Field NMR as a Vital Spectral Tool in Organic Chemistry. Preprints. https://doi.org/10.20944/preprints202405.1220.v1
Chicago/Turabian Style
Gašparová, M., Simona Ilková and Zita Tokárová. 2024 "Low-Field NMR as a Vital Spectral Tool in Organic Chemistry" Preprints. https://doi.org/10.20944/preprints202405.1220.v1
Abstract
The growing interest in benchtop NMR systems is visible in a vast number of applications in science and industry. Low-field nuclear magnetic resonance (LF-NMR) became an instant in technologies that productions are dependent on the reliable structure identification, grade and purity control, chemical process inspection or reaction monitoring. Beyond the benefits of being cost-, space-, maintenance- and user friendly, insufficient sensitivity and low signal resolution are the main drawbacks, due to which the low-field NMR (LF-NMR) in the fields of organic chemistry and synthesis remains limited to solely academic teaching purposes. Herein, we discuss the possibilities of LF-NMR for the needs of organic chemistry and synthesis on a set of compounds 1-4 achieved as the products of student’s laboratory course and organic derivatives 5-8 that are from our research interests. Chemical structure determination of all compounds 1-8 presented herein was performed using the benchtop-type NMR instrument operating at 60 MHz (Pulsar Oxford Ltd.). Structure of novel compounds 5-7 prepared under the aims of our research was characterized by combined 1H/19LF-NMR and compared with an appropriate high-field NMR data from Bruker Ascend Instrument (400 MHz). Finally, possibilities of the low-field NMR as an analytical tool for the research purposes in the fields of organic chemistry and synthesis are documented on a set of 1H and 2D 1H-1H COSY for azomethine 8.
Chemistry and Materials Science, Organic Chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
