Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; Kulchitsky, V.A.; Potkin, V.I.; Pushkarchuk, A.L.; Lyakhov, D.A.; Michels, D.L. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules2024, 29, 3246.
Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; Kulchitsky, V.A.; Potkin, V.I.; Pushkarchuk, A.L.; Lyakhov, D.A.; Michels, D.L. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules 2024, 29, 3246.
Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; Kulchitsky, V.A.; Potkin, V.I.; Pushkarchuk, A.L.; Lyakhov, D.A.; Michels, D.L. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules2024, 29, 3246.
Mukusheva, G.K.; Jalmakhanbetova, R.I.; Shaibek, A.Z.; Nurmaganbetova, M.S.; Zhasymbekova, A.R.; Nurkenov, O.A.; Akishina, E.A.; Kolesnik, I.A.; Dikusar, E.A.; Terpinskaya, T.I.; Kulchitsky, V.A.; Potkin, V.I.; Pushkarchuk, A.L.; Lyakhov, D.A.; Michels, D.L. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells. Molecules 2024, 29, 3246.
Abstract
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor ac-tivity in combination with the commonly used six anticancer drugs namely cyclophosphane, fluorouracil, etoposide, cysplatine, ribomustine with different mechanisms of action was investi-gated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting on the С6 rat glioma model cells.
Keywords
anabasine; cytisine; ureas; isoxazole; cytotoxic activity; antiproliferative activity; drug synergism; quantum chemical modeling molecular dockin
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
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