Jager, A.; Oddens, J.R.; Postema, A.W.; Miclea, R.L.; Schoots, I.G.; Nooijen, P.G.T.A.; van der Linden, H.; Barentsz, J.O.; Heijmink, S.W.T.P.J.; Wijkstra, H.; Mischi, M.; Turco, S. Is There an Added Value of Quantitative DCE-MRI by Magnetic Resonance Dispersion Imaging for Prostate Cancer Diagnosis? Cancers2024, 16, 2431.
Jager, A.; Oddens, J.R.; Postema, A.W.; Miclea, R.L.; Schoots, I.G.; Nooijen, P.G.T.A.; van der Linden, H.; Barentsz, J.O.; Heijmink, S.W.T.P.J.; Wijkstra, H.; Mischi, M.; Turco, S. Is There an Added Value of Quantitative DCE-MRI by Magnetic Resonance Dispersion Imaging for Prostate Cancer Diagnosis? Cancers 2024, 16, 2431.
Jager, A.; Oddens, J.R.; Postema, A.W.; Miclea, R.L.; Schoots, I.G.; Nooijen, P.G.T.A.; van der Linden, H.; Barentsz, J.O.; Heijmink, S.W.T.P.J.; Wijkstra, H.; Mischi, M.; Turco, S. Is There an Added Value of Quantitative DCE-MRI by Magnetic Resonance Dispersion Imaging for Prostate Cancer Diagnosis? Cancers2024, 16, 2431.
Jager, A.; Oddens, J.R.; Postema, A.W.; Miclea, R.L.; Schoots, I.G.; Nooijen, P.G.T.A.; van der Linden, H.; Barentsz, J.O.; Heijmink, S.W.T.P.J.; Wijkstra, H.; Mischi, M.; Turco, S. Is There an Added Value of Quantitative DCE-MRI by Magnetic Resonance Dispersion Imaging for Prostate Cancer Diagnosis? Cancers 2024, 16, 2431.
Abstract
In this multicenter, retrospective study we evaluated the added value of magnetic resonance dispersion imaging (MRDI) to standard multiparametric MRI (mpMRI) for PCa detection. The study included 76 patients - 51 with clinically significant prostate cancer (csPCa), who underwent radical prostatectomy and had an mpMRI including dynamic contrast enhanced-MRI. Two radiologists performed three separate randomized scorings based on mpMRI, MRDI and mpMRI+MRDI. Radical prostatectomy histopathology was used as the reference standard. Imaging and histopathology were both scored according to the Prostate Imaging-Reporting and Data System V2.0 sector map. Sensitivity and specificity for PCa detection were evaluated for mpMRI, MRDI and mpMRI+MRDI. Inter- and intra-observer variability for both radiologists were evaluated using Cohen’s Kappa. On a per patient level, sensitivity for csPCa for radiologist 1 (R1) for mpMRI, MRDI and mpMRI+MRDI were 0.94, 0.82 and 0.94, respectively. For the second radiologist (R2) these were 0.78, 0.94 and 0.96. R1 detected 4% additional csPCa cases using MRDI compared to mpMRI and R2 detected 20% extra csPCa cases using MRDI. Inter-observer agreement was significant only for MRDI (Cohen’s kappa = 0.4250, p=0.004). The results of this study show the potential of MRDI to improve interobserver variability and the detection of csPCa.
Medicine and Pharmacology, Oncology and Oncogenics
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