Article
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The Photochemical Isomerization in Pyridazine-N-oxide Derivatives
Version 1
: Received: 29 May 2024 / Approved: 30 May 2024 / Online: 30 May 2024 (08:12:30 CEST)
How to cite: D’Auria, M.; Emanuele, L. The Photochemical Isomerization in Pyridazine-N-oxide Derivatives. Preprints 2024, 2024052011. https://doi.org/10.20944/preprints202405.2011.v1 D’Auria, M.; Emanuele, L. The Photochemical Isomerization in Pyridazine-N-oxide Derivatives. Preprints 2024, 2024052011. https://doi.org/10.20944/preprints202405.2011.v1
Abstract
DFT calculations on the photoisomerization reactions of pyridazine N-oxide derivatives are presented. The irradiation of 3,6-diphenylpyridazine N-oxide allowed to obtain the first excited singlet state that underwent to a ring opening reaction induced to the oxygen migration to the adjacent carbon atom, with the formation of a diazo derivative. This intermediate can give a ring closure reaction to give a pyrazole derivative, or, with a higher transition energy, it can lose nitrogen allowing the formation of 2,5-diphenylfuran. The irradiation of 3-phenylpyridazine N-oxide allowed the formation only of 2-phenylfuran. In this case, calculations allowed to explain this behavior. The first excited singlet state gave a photoisomerization reaction with the formation of the corresponding diazo intermediate. This intermediate could not be converted into the corresponding pyrazole derivative because it was converted into a N-formyl pyrazole never reported in literature. The only possible reaction is the loss of nitrogen and the formation of 2-phenylfuran.
Keywords
pyridazine N-oxide; photoisomerization; DFT calculations; pyrazole; furan.
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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