Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Porvac® Subunit Vaccine Confers Full Protection against Three Field Isolates of Classical Swine Fever Virus

Yusmel Sordo-Puga
* ,
María Pilar Rodríguez-Moltó
,
Danny Pérez-Pérez
,
Paula Naranjo Valdéz
,
Talia Sardina González
,
Mary Karla Mendez Orta
,
Elaine Santana-Rodríguez
,
Milagros Vargas-Hernández
,
Carmen Laura Perera
,
Carlos A. Duarte
,
Marisela Suárez Pedroso
Version 1 : Received: 4 June 2024 / Approved: 5 June 2024 / Online: 5 June 2024 (10:30:59 CEST)

How to cite: Sordo-Puga, Y.; Rodríguez-Moltó, M. P.; Pérez-Pérez, D.; Naranjo Valdéz, P.; Sardina González, T.; Mendez Orta, M. K.; Santana-Rodríguez, E.; Vargas-Hernández, M.; Laura Perera, C.; Duarte, C. A.; Suárez Pedroso, M. Porvac® Subunit Vaccine Confers Full Protection against Three Field Isolates of Classical Swine Fever Virus. Preprints 2024, 2024060269. https://doi.org/10.20944/preprints202406.0269.v1 Sordo-Puga, Y.; Rodríguez-Moltó, M. P.; Pérez-Pérez, D.; Naranjo Valdéz, P.; Sardina González, T.; Mendez Orta, M. K.; Santana-Rodríguez, E.; Vargas-Hernández, M.; Laura Perera, C.; Duarte, C. A.; Suárez Pedroso, M. Porvac® Subunit Vaccine Confers Full Protection against Three Field Isolates of Classical Swine Fever Virus. Preprints 2024, 2024060269. https://doi.org/10.20944/preprints202406.0269.v1

Abstract

The control of classical swine fever (CSF) in endemic areas has been attempted with modified live vaccines. However, in some regions, the implementation of imperfect vaccination programs has led to a reduction in the genetic diversity of the circulating strains and a change in their virulence. Porvac® subunit vaccine has been shown to provide a rapid onset of protection against the “Margarita” strain. The aim of this study was to evaluate whether the immune response induced by Porvac® is also effective against autochthonous isolates of low, medium or high virulence. All pigs vaccinated with Porvac® were protected against the disease after the challenge. PR-11/10–3 isolate caused a very mild disease in controls, whilst Holguin_2009 isolate produced mild to moderate signs of CSF and one of the pigs died. Finally, controls inoculated with PR-2016 isolate developed moderate to severe signs of CSF and two of them died. Viral replication was detected in controls, but not in pigs immunized with Porvac®. Finally, anti-Erns antibodies were induced in five out of six control pigs but in any of the vaccinated pigs. These results support the use of Porvac® for the control and elimination of CSF in Cuba and other endemic regions.

Keywords

classical swine fever; vaccine; Porvac®; field isolates; viral challenge

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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