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Copper Supplementation in Young Wistar Rats
Version 1
: Received: 6 June 2024 / Approved: 6 June 2024 / Online: 7 June 2024 (02:51:26 CEST)
How to cite: Kitala–Tańska, K.; Hanć, A.; Juśkiewicz, J.; Majewski, M. Copper Supplementation in Young Wistar Rats. Preprints 2024, 2024060396. https://doi.org/10.20944/preprints202406.0396.v1 Kitala–Tańska, K.; Hanć, A.; Juśkiewicz, J.; Majewski, M. Copper Supplementation in Young Wistar Rats. Preprints 2024, 2024060396. https://doi.org/10.20944/preprints202406.0396.v1
Abstract
Supplementation with 200% of the recommended daily dietary quantity of copper modified vascular contraction and relaxation through increased reactive oxygen species (ROS) and prostaglandin formation, which modified the antioxidant status of middle–aged rats. In this study, young (1 month old) male Wistar rats (n/group = 10) received a diet supplemented with 6.45 mg copper/kg (100%—Group A) for 8 weeks. The experimental group received 12.9 mg copper/kg of diet (200%—Group B). Experimental supplementation with 200% copper increased the copper concentration in the blood, liver, and kidneys; increased the ROS concentration in the aortic rings; and enhanced the sensitivity of the aortic rings to acetylcholine. We observed increased participation of nitric oxide (NO) derived from inducible NO synthase (iNOS) in vascular contraction and a decreased net effect of vasodilator prostanoids derived from cyclooxygenase–2 (COX–2) in vascular relaxation. Supplementation with 200% copper was less significant than expected after previous studies conducted with middle–aged rats.
Keywords
aortic rings; copper; vascular studies
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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