Vamesu, S.; Ursica, O.A.; Milea, S.E.; Deacu, M.; Aschie, M.; Mitroi, A.F.; Voinea, F.; Pundiche, M.B.; Orasanu, C.I.; Voda, R.I. Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas. Medicina2024, 60, 1126.
Vamesu, S.; Ursica, O.A.; Milea, S.E.; Deacu, M.; Aschie, M.; Mitroi, A.F.; Voinea, F.; Pundiche, M.B.; Orasanu, C.I.; Voda, R.I. Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas. Medicina 2024, 60, 1126.
Vamesu, S.; Ursica, O.A.; Milea, S.E.; Deacu, M.; Aschie, M.; Mitroi, A.F.; Voinea, F.; Pundiche, M.B.; Orasanu, C.I.; Voda, R.I. Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas. Medicina2024, 60, 1126.
Vamesu, S.; Ursica, O.A.; Milea, S.E.; Deacu, M.; Aschie, M.; Mitroi, A.F.; Voinea, F.; Pundiche, M.B.; Orasanu, C.I.; Voda, R.I. Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas. Medicina 2024, 60, 1126.
Abstract
Background and Objectives: Renal cell carcinomas and upper tract urothelial carcinomas are types of malignancies that originate in the kidneys. Each of these examples shows an increasing trend in the frequency and the mortality rate. This study aims to comprehensively define carcinomas by analysing clinical, paraclinical, and histological aspects to predict aggressiveness and mortality. Materials and Methods: We conducted a retrospective investigation on a group of patients suspected with kidney cancers. Results: We identified 188 cases. We observed a higher mortality rate and older age in individuals with urothelial carcinomas. Anemia, acute kidney injury, hematuria and perineural invasion were the main risk factors that predicted their mortality. Tumour size in renal cell carcinomas correlates with the presence of necrosis and sarcomatoid areas. Factors that indicate a higher rate of death are older age, exceeding of the renal capsule, the lesion that includes the entire kidney, lymphovascular invasion, acute kidney injury, and anemia. Conclusions: Even if they originate at the renal level, and the clinical-paraclinical picture is similar, the histopathological characteristics make the difference. In addition, to these are added the previously mentioned common parameters that can represent important prognostic factors. In conclusion, the characteristics commonly identified in one type of cancer may act as risk factors for the other tumor. The detected data include threshold values and risk factors, making a significant contribution to the existing literature.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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