An Optofluidic Young Interferometer for Electrokinetic Transport Coupled Biosensing

Elisabetta Labella; Ruchi Gupta

doi:10.20944/preprints202406.0591.v1

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preprints.org > chemistry and materials science > analytical chemistry > doi: 10.20944/preprints202406.0591.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

An Optofluidic Young Interferometer for Electrokinetic Transport Coupled Biosensing

Elisabetta Labella

and

Ruchi Gupta

Version 1 : Received: 7 June 2024 / Approved: 10 June 2024 / Online: 10 June 2024 (14:35:55 CEST)

A peer-reviewed article of this Preprint also exists.

Labella, E.; Gupta, R. An Optofluidic Young Interferometer for Electrokinetic Transport-Coupled Biosensing. Micromachines 2024, 15, 861. Labella, E.; Gupta, R. An Optofluidic Young Interferometer for Electrokinetic Transport-Coupled Biosensing. Micromachines 2024, 15, 861.

Abstract

Label-free optical biosensors such as interferometers can provide comparable limit of detection to widely used enzyme-linked immunosorbent assays, while minimizing the number of steps and reducing false positives/ negatives. In 2020, authors reported a novel optofluidic Young interferometer (YI) that can provide real-time spatial information on refractive index changes occurring along the length of sensor and reference channels. Herein, we exploited these features of the YI to study interactions of biomolecules with recognition elements immobilized in selected regions of agarose gel in the sensor channel. We showed that the YI is well suited for biosensing of an exemplar biomolecule, streptavidin, in the absence and presence of bovine serum albumin interferent. Equally, we coupled the YI with electrokinetic transport to reduce the time for biosensing.

Keywords

Young interferometer; electrokinetic; microfluidics; biosensing; streptavidin

Subject

Chemistry and Materials Science, Analytical Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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