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Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area
Version 1
: Received: 10 June 2024 / Approved: 11 June 2024 / Online: 11 June 2024 (15:32:58 CEST)
How to cite:
Apostolidi, E. A.; Basoulis, D.; Zerva, S.; Karapanou, A.; Pantazatou, A.; Deliolanis, I.; Markogiannakis, A.; Sipsas, N. V.; Gamaletsou, M. N. Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area. Preprints2024, 2024060719. https://doi.org/10.20944/preprints202406.0719.v1
Apostolidi, E. A.; Basoulis, D.; Zerva, S.; Karapanou, A.; Pantazatou, A.; Deliolanis, I.; Markogiannakis, A.; Sipsas, N. V.; Gamaletsou, M. N. Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area. Preprints 2024, 2024060719. https://doi.org/10.20944/preprints202406.0719.v1
Apostolidi, E. A.; Basoulis, D.; Zerva, S.; Karapanou, A.; Pantazatou, A.; Deliolanis, I.; Markogiannakis, A.; Sipsas, N. V.; Gamaletsou, M. N. Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area. Preprints2024, 2024060719. https://doi.org/10.20944/preprints202406.0719.v1
APA Style
Apostolidi, E. A., Basoulis, D., Zerva, S., Karapanou, A., Pantazatou, A., Deliolanis, I., Markogiannakis, A., Sipsas, N. V., & Gamaletsou, M. N. (2024). Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area. Preprints. https://doi.org/10.20944/preprints202406.0719.v1
Chicago/Turabian Style
Apostolidi, E. A., Nikolaos V Sipsas and Maria N Gamaletsou. 2024 "Blood Stream Infections due to Carbapenem-Resistant Gram-Negative Bacilli, Producing Klebsiella pneumoniae Carbapenemase or New Delhi Metallo-β-Lactamase: A Single-Center, Retrospective, Comparative Study in a High-Prevalence Area" Preprints. https://doi.org/10.20944/preprints202406.0719.v1
Abstract
Blood stream infections (BSI) due to carbapenem-resistant gram-negative bacilli (CR-GNB), especially Klebsiella pneumoniae carbapenemase (KPC) and New-Delhi metallo-β-lactamase (NDM) producers, are a major concern of public health, as they are associated with high morbidity and mortality. We conducted a single-center, retrospective, observational study at a tertiary-care, teaching Greek hospital, to determine the incidence, 30-day and overall, in-hospital, crude mortality, risk factors and efficacy of best available treatment options in patients with BSIs from KPC- or NDM-producing GR-GNB. During the one-year study period, from 1st January to 31st December 2023, we recorded 133 episodes of BSIs in 118 unique patients; 79 episodes were due to KPC-producing and 54 to NDM-producing CR-GNB. Our study showed relatively high incidence of BSIs by both KPC- and NDM-producing CR-GNB (0.49 and 0.31 episodes per 1000 patient-days respectively). We found high 30-day crude mortality rates for patients with BSIs due to KPC- producing CR-GNB (26.4 %), and NDM-producing CR-GNB (37%), while BSIs due to NDM-producing P. aeruginosa had the highest 30-day (47.1%) and overall (70.6%) in-hospital, crude mortality. Beta-lactam/beta-lactamase inhibitors as monotherapy or in combination with other active agents used to treat KPC-producing CR-GNB were associated with improved survival rates (p=0.009).
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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