Version 1
: Received: 10 June 2024 / Approved: 11 June 2024 / Online: 12 June 2024 (12:17:37 CEST)
How to cite:
Jeeunngoi, J.; Senawong, G.; Jogloy, S.; Prompipak, J.; Samankul, A.; Utaiwat, S.; Woranam, K.; Sripa, B.; Senawong, T. Anticancer Potential of Valencia Peanut (Arachis hypogaea L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models. Preprints2024, 2024060761. https://doi.org/10.20944/preprints202406.0761.v1
Jeeunngoi, J.; Senawong, G.; Jogloy, S.; Prompipak, J.; Samankul, A.; Utaiwat, S.; Woranam, K.; Sripa, B.; Senawong, T. Anticancer Potential of Valencia Peanut (Arachis hypogaea L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models. Preprints 2024, 2024060761. https://doi.org/10.20944/preprints202406.0761.v1
Jeeunngoi, J.; Senawong, G.; Jogloy, S.; Prompipak, J.; Samankul, A.; Utaiwat, S.; Woranam, K.; Sripa, B.; Senawong, T. Anticancer Potential of Valencia Peanut (Arachis hypogaea L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models. Preprints2024, 2024060761. https://doi.org/10.20944/preprints202406.0761.v1
APA Style
Jeeunngoi, J., Senawong, G., Jogloy, S., Prompipak, J., Samankul, A., Utaiwat, S., Woranam, K., Sripa, B., & Senawong, T. (2024). Anticancer Potential of Valencia Peanut (<em>Arachis hypogaea </em>L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models. Preprints. https://doi.org/10.20944/preprints202406.0761.v1
Chicago/Turabian Style
Jeeunngoi, J., Banchob Sripa and Thanaset Senawong. 2024 "Anticancer Potential of Valencia Peanut (<em>Arachis hypogaea </em>L.) Skin Extract against Cervical Cancer Cells In Vitro and in Nude Mouse Xenograft Models" Preprints. https://doi.org/10.20944/preprints202406.0761.v1
Abstract
Abstract: This study aimed at investigating the effects of Valencia KK4-type peanut skin ethanolic extract (KK4-PSE) in combination with cisplatin or 5-fluorouracil (5-FU) against HeLa cells in vitro and in xenograft models. MTT assay showed that KK4-PSE, cisplatin, and 5-FU suppressed proliferation of HeLa cells in a dose and time dependent manner. Drug interactions by Chou-Talalay method demonstrated that KK4-PSE enhanced antiproliferative activity of 5-FU against HeLa cells with combination index (CI) values of 0.49 (48 h) and 0.60 (72 h), indicating a synergistic effect, while KK4-PSE combined with cisplatin exhibited an additive effect (CI = 1.02) (72 h) and antagonistic effect at 24 and 48 h exposures (CI = 1.12 and 1.18, respectively). In nude mouse xenograft models, the combination of 5-FU and KK4-PSE markedly reduced HeLa tumor weights compared with control and single agent treatments. The combination of KK4-PSE and 5-FU achieved greater tumor growth inhibition than that of the KK4-PSE-cisplatin combination. KK4-PSE mitigated hepatotoxicity induced by both cisplatin and 5-FU in nude mice. The spleen hyaloserositis was significantly reduced in the combination treatment of 5-FU and KK4-PSE. These findings suggest a potential of KK4-PSE to inhibit cervical cancer cell growth while alleviating the toxicities of cisplatin and 5-FU.
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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