PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods
Version 1
: Received: 11 June 2024 / Approved: 11 June 2024 / Online: 12 June 2024 (11:13:14 CEST)
How to cite:
El Deeb, S. Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods. Preprints2024, 2024060778. https://doi.org/10.20944/preprints202406.0778.v1
El Deeb, S. Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods. Preprints 2024, 2024060778. https://doi.org/10.20944/preprints202406.0778.v1
El Deeb, S. Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods. Preprints2024, 2024060778. https://doi.org/10.20944/preprints202406.0778.v1
APA Style
El Deeb, S. (2024). Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods. Preprints. https://doi.org/10.20944/preprints202406.0778.v1
Chicago/Turabian Style
El Deeb, S. 2024 "Enhancing Sustainable Analytical Chemistry in Liquid Chromatography: Guideline for Transferring Classical HPLC and UHPLC Methods into Greener, Bluer, and Whiter Methods" Preprints. https://doi.org/10.20944/preprints202406.0778.v1
Abstract
This review is dedicated to sustainable practices in liquid chromatography. HPLC and UHPLC methods contribute significantly to routine analytical techniques. Therefore, the transfer of classical liquid chromatographic methods into sustainable ones is of utmost importance in moving toward sustainable development goals. Among other principles to render a liquid chromatographic method green, substitution of the organic solvent component in the mobile phase with a greener one received great attention. This review concentrates on choosing the best alternative green organic solvent to replace the classical solvent in the mobile phase for easy rapid transfer to a more sustainable normal phase or reversed-phase liquid chromatography. The main focus of this review will be on describing the transfer of non-green to green and white chromatographic methods in an effort to elevate the sustainability best practice in analytical chemistry. The greenness properties and greenness ranking in addition to the chromatographic suitability of seventeen organic solvents for liquid chromatography are mentioned to have a clear insight into the issue of rapidly choosing the appropriate solvent to transfer a classical HPLC or UHPLC method into a more sustainable one. A simple guide is proposed for making the liquid chromatographic method more sustainable.
Keywords
green chemistry; green analytical chemistry; blue analytical chemistry; white analytical chemistry; sustainable analytical chemistry; sustainability; sustainable development; sustainability guideline; solvent selection; liquid chromatography
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
