Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Profiles in Autism Spectrum Disorder: Enhancing Diagnosis, Treatment, and Overall Health Outcomes

Version 1 : Received: 12 June 2024 / Approved: 12 June 2024 / Online: 12 June 2024 (14:33:42 CEST)

How to cite: Machado Cruz, T. Clinical Profiles in Autism Spectrum Disorder: Enhancing Diagnosis, Treatment, and Overall Health Outcomes. Preprints 2024, 2024060856. https://doi.org/10.20944/preprints202406.0856.v1 Machado Cruz, T. Clinical Profiles in Autism Spectrum Disorder: Enhancing Diagnosis, Treatment, and Overall Health Outcomes. Preprints 2024, 2024060856. https://doi.org/10.20944/preprints202406.0856.v1

Abstract

Autism Spectrum Disorder (ASD), a neurodevelopmental disorder, is increasingly diagnosed and significantly affects communication, behavior, and social interaction. The current diagnostic framework, guided by the DSM-5, has limitations that may lead to clinical gaps due to overlapping symptoms of ASD and other disorders. This study proposes a comprehensive approach to enhance ASD diagnosis through clinical stratification based on comorbidities. We applied precision medicine techniques to identify and categorize ASD into ten clinical profiles. Our findings contribute to a more profound understanding of ASD, including its varied clinical manifestations and comorbidities, and facilitate the development of personalized therapeutic strategies.

Keywords

autism spectrum disorder; precision medicine; clinical profiles; mitochondrial dysfunction; nutritional strategies; genetic variants; integrative care; translational medicine; comorbidities; neuroinflammation

Subject

Medicine and Pharmacology, Clinical Medicine

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