Version 1
: Received: 12 June 2024 / Approved: 13 June 2024 / Online: 13 June 2024 (05:37:09 CEST)
How to cite:
Piatti, G.; Girotto, G.; Concas, M. P.; Braga, L.; Ambrosetti, U.; Aldè, M. TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia. Preprints2024, 2024060885. https://doi.org/10.20944/preprints202406.0885.v1
Piatti, G.; Girotto, G.; Concas, M. P.; Braga, L.; Ambrosetti, U.; Aldè, M. TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia. Preprints 2024, 2024060885. https://doi.org/10.20944/preprints202406.0885.v1
Piatti, G.; Girotto, G.; Concas, M. P.; Braga, L.; Ambrosetti, U.; Aldè, M. TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia. Preprints2024, 2024060885. https://doi.org/10.20944/preprints202406.0885.v1
APA Style
Piatti, G., Girotto, G., Concas, M. P., Braga, L., Ambrosetti, U., & Aldè, M. (2024). TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia. Preprints. https://doi.org/10.20944/preprints202406.0885.v1
Chicago/Turabian Style
Piatti, G., Umberto Ambrosetti and Mirko Aldè. 2024 "TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia" Preprints. https://doi.org/10.20944/preprints202406.0885.v1
Abstract
(1) Background: Several chronic respiratory diseases could be a risk factor for acquiring SARS-CoV-2 infection: among them, Primary Ciliary Dyskinesia (PCD) is a rare (about 1:10.000) inherited ciliopathy (MIM 242650) characterized by recurrent upper and lower respiratory tract infections due to a dysfunctioning of the respiratory cilia; We aimed to investigate if some polymorphisms of the TAS2R38 bitter taste receptor correlate with an increased prevalence of SARS-CoV-2 infection and severity of symptoms in a cohort of PCD subjects; (2) Methods: Patients answered several questions about possible SARS-CoV-2 infection, experienced symptoms and vaccinations; in case of infection, they also filled out a SNOT-22 and ARTIQ questionnaires; (3) Results: Forty PCD adult patients (mean age 36.6 ± 16.7 years, 23 females) participated to the study, out of which 30 % had tested positive for COVID-19 during the last four years; most of them reported a mildly symptomatic disease. We found no differences in age or sex, but a statistic significant difference (p=0.03) was observed in body mass index (BMI), that was higher in the COVID-acquired group (23.2 ± 3.3 vs 20.1 ± 4.1 kg/m2). Genotyping for TAS2R38 polymorphisms showed a prevalence of 28.6% PAV/PAV, 48.6% PAV/AVI and 22.8% AVI/AVI individuals in our cohort. In contrast to our hypothesis, we did not observe a protective role of PAV allele towards SARS-CoV-2 infection; (4) Conclusions: Our findings suggest that subjects with PCD may not be at increased risk of severe outcomes from COVID-19 and the TAS2R38 bitter taste receptor genotype type does not affect SARS-CoV-2 infection.
Public Health and Healthcare, Public, Environmental and Occupational Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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