Benralizumab: The Immuno-Pharmacological State of the Art

Alessandra Vultaggio; Marco Benci; Laura Bergantini; Claudia Crimi; Laura Malerba; Andrea Matucci; Francesco Menzella; Jan Walter Schroeder; Gianenrico Senna; Carola Vetriolo; Paolo Cameli

doi:10.20944/preprints202406.1014.v1

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preprints.org > medicine and pharmacology > immunology and allergy > doi: 10.20944/preprints202406.1014.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Benralizumab: The Immuno-Pharmacological State of the Art

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Version 1 : Received: 14 June 2024 / Approved: 14 June 2024 / Online: 14 June 2024 (14:14:27 CEST)

How to cite: Vultaggio, A.; Benci, M.; Bergantini, L.; Crimi, C.; Malerba, L.; Matucci, A.; Menzella, F.; Schroeder, J. W.; Senna, G.; Vetriolo, C.; Cameli, P. Benralizumab: The Immuno-Pharmacological State of the Art. Preprints 2024, 2024061014. https://doi.org/10.20944/preprints202406.1014.v1 Vultaggio, A.; Benci, M.; Bergantini, L.; Crimi, C.; Malerba, L.; Matucci, A.; Menzella, F.; Schroeder, J. W.; Senna, G.; Vetriolo, C.; Cameli, P. Benralizumab: The Immuno-Pharmacological State of the Art. Preprints 2024, 2024061014. https://doi.org/10.20944/preprints202406.1014.v1

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MDPI and ACS Style

Vultaggio, A.; Benci, M.; Bergantini, L.; Crimi, C.; Malerba, L.; Matucci, A.; Menzella, F.; Schroeder, J. W.; Senna, G.; Vetriolo, C.; Cameli, P. Benralizumab: The Immuno-Pharmacological State of the Art. Preprints 2024, 2024061014. https://doi.org/10.20944/preprints202406.1014.v1

APA Style

Vultaggio, A., Benci, M., Bergantini, L., Crimi, C., Malerba, L., Matucci, A., Menzella, F., Schroeder, J. W., Senna, G., Vetriolo, C., & Cameli, P. (2024). Benralizumab: The Immuno-Pharmacological State of the Art. Preprints. https://doi.org/10.20944/preprints202406.1014.v1

Chicago/Turabian Style

Vultaggio, A., Carola Vetriolo and Paolo Cameli. 2024 "Benralizumab: The Immuno-Pharmacological State of the Art" Preprints. https://doi.org/10.20944/preprints202406.1014.v1

Abstract

Eosinophils are key therapeutic targets in severe asthma as they accumulate in tissues, resulting in local damage through the release of toxic mediators. Benralizumab is a monoclonal antibody with a direct anti-eosinophilic activity that has proved significant clinical efficacy in patients with severe eosinophilic asthma, and its use in real-life went well beyond what we had expected from the pivotal trials, especially in the reduction of asthma exacerbations and oral steroids usage. Benralizumab induces eosinophil apoptosis due to a mechanism of antibody-dependent cell-mediated cytotoxicity by natural killer (NK) cells. Within this review, we will discuss benralizumab pharmacological and pharmacokinetic aspects in the treatment of severe asthma, with an emphasis on the novel immunological effects of benralizumab on NK cells. Overall, these findings account for the clinical efficacy and safety profile of benralizuamb, previously described in patients with an eosinophilic phenotype of the disease.

Keywords

benralizumab

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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