Version 1
: Received: 16 June 2024 / Approved: 17 June 2024 / Online: 17 June 2024 (08:05:58 CEST)
How to cite:
Pio, F.; Murdock, A.; Fuller, R. E.; Whalen, M. J. The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer. Preprints2024, 2024061099. https://doi.org/10.20944/preprints202406.1099.v1
Pio, F.; Murdock, A.; Fuller, R. E.; Whalen, M. J. The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer. Preprints 2024, 2024061099. https://doi.org/10.20944/preprints202406.1099.v1
Pio, F.; Murdock, A.; Fuller, R. E.; Whalen, M. J. The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer. Preprints2024, 2024061099. https://doi.org/10.20944/preprints202406.1099.v1
APA Style
Pio, F., Murdock, A., Fuller, R. E., & Whalen, M. J. (2024). The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer. Preprints. https://doi.org/10.20944/preprints202406.1099.v1
Chicago/Turabian Style
Pio, F., Renee E. Fuller and Michael J. Whalen. 2024 "The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer" Preprints. https://doi.org/10.20944/preprints202406.1099.v1
Abstract
Prostate cancer is the most common non-cutaneous malignancy in men, with the majority of newly diagnosed patients eligible for active surveillance. Despite definitive treatment, a considerable percentage of men will experience biochemical recurrence and even regional and distant metastatic recurrence after radiation therapy or radical prostatectomy. Salvage prostatectomy, while oncologically effective, poses significant morbidity with poor functional outcomes. Salvage cryotherapy has emerged as a promising alternative for localized recurrence, demonstrating safety and efficacy. This review examines the oncologic and functional outcomes of whole-gland and focal salvage cryotherapy, including disease-free survival, cancer-specific survival, and overall survival. The crucial role of multiparametric prostate MRI and evolving role of next-generation PSMA-targeted PET imaging is also examined. Comparison of outcomes of cryotherapy to other salvage ablation modalities, such as high-intensity focused ultrasound (HIFU) is also explored.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
