Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preparation and Characterization of a Novel Hydroxyapatite-Capsaicin Composite Intended for the In-Office Dental Bleaching Use

Karine Letícia da Silva
ORCID logo ,
Diego Hortkoff
,
Michael William Favoreto
ORCID logo ,
Marcia Rezende
ORCID logo ,
Jessica Mendes Nadal
,
Ana Armas-Vega
,
Alessandro D. Loguercio
* ORCID logo ,
Paulo Vitor Farago
ORCID logo
Version 1 : Received: 14 June 2024 / Approved: 18 June 2024 / Online: 18 June 2024 (09:33:23 CEST)

How to cite: Silva, K. L. D.; Hortkoff, D.; Favoreto, M. W.; Rezende, M.; Nadal, J. M.; Armas-Vega, A.; Loguercio, A. D.; Farago, P. V. Preparation and Characterization of a Novel Hydroxyapatite-Capsaicin Composite Intended for the In-Office Dental Bleaching Use. Preprints 2024, 2024061197. https://doi.org/10.20944/preprints202406.1197.v1 Silva, K. L. D.; Hortkoff, D.; Favoreto, M. W.; Rezende, M.; Nadal, J. M.; Armas-Vega, A.; Loguercio, A. D.; Farago, P. V. Preparation and Characterization of a Novel Hydroxyapatite-Capsaicin Composite Intended for the In-Office Dental Bleaching Use. Preprints 2024, 2024061197. https://doi.org/10.20944/preprints202406.1197.v1

Abstract

The aim of this study was to synthetize a hydroxyapatite-capsaicin composite (HAp-CAP) and to evaluate its physicochemical data for further use in hydrogen peroxide in-office dental bleaching gel. The HAp-CAP was prepared by the precipitation method, performed in a 4:1 ratio using 3.2 g of nano-hydroxyapatite (nano-HAp) and 0.8 g of capsaicin (CAP) in 99.5% ethyl alcohol (q.s.p) and zirconia beads at SpeedMixer®. The HAp-CAP was characterized by morphological, spectroscopic, and thermal analyses. In the following, the HAp-CAP was added to an in-office dental bleaching to test its effect on reducing hydrogen peroxide diffusion into the pulp chamber, as well as the effect in the color alteration during dental bleaching. The HAp-CAP were suitably obtained by the precipitation method, and the results demonstrates that the thermal stability of the CAP is greatly improved after reaction of HAp and CAP. The HAp-CAP into a bleaching gel slightly decreased the amount of hydrogen peroxide inside the pulp chamber and didn’t interfering in the bleaching effectiveness of dental bleaching. The HAp-CAP synthesis and characterization were successfully carried out, and its use in dental materials is a challenging task that needs further study since its addition.

Keywords

dental enamel permeability; tooth bleaching; hydrogen peroxide; tooth sensitivity; TRPA-1 receptors.

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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