Version 1
: Received: 18 June 2024 / Approved: 18 June 2024 / Online: 18 June 2024 (11:16:13 CEST)
Version 2
: Received: 18 June 2024 / Approved: 19 June 2024 / Online: 19 June 2024 (11:17:51 CEST)
How to cite:
Rogers, C.; Thorp, J. A.; Cosgrove, K.; McCullough, P. A. COVID-19 Vaccines: A Risk Factor for Cerebral Thrombotic Syndromes. Preprints2024, 2024061236. https://doi.org/10.20944/preprints202406.1236.v2
Rogers, C.; Thorp, J. A.; Cosgrove, K.; McCullough, P. A. COVID-19 Vaccines: A Risk Factor for Cerebral Thrombotic Syndromes. Preprints 2024, 2024061236. https://doi.org/10.20944/preprints202406.1236.v2
Rogers, C.; Thorp, J. A.; Cosgrove, K.; McCullough, P. A. COVID-19 Vaccines: A Risk Factor for Cerebral Thrombotic Syndromes. Preprints2024, 2024061236. https://doi.org/10.20944/preprints202406.1236.v2
APA Style
Rogers, C., Thorp, J. A., Cosgrove, K., & McCullough, P. A. (2024). COVID-19 Vaccines: A Risk Factor for Cerebral Thrombotic Syndromes. Preprints. https://doi.org/10.20944/preprints202406.1236.v2
Chicago/Turabian Style
Rogers, C., Kirstin Cosgrove and Peter A McCullough. 2024 "COVID-19 Vaccines: A Risk Factor for Cerebral Thrombotic Syndromes" Preprints. https://doi.org/10.20944/preprints202406.1236.v2
Abstract
Introduction: This population-based retrospective cohort study assesses rates of adverse events (AEs) involving cerebral thromboembolism (CTE) after COVID-19 vaccines. Methods: Data were collected from the U.S. Centers for Disease Control and Prevention (CDC) and Food and Drug Administration (FDA) Vaccine Adverse Event Reporting System (VAERS) database from January 1, 1990 to December 31, 2023. CTE AEs after COVID-19 vaccines were compared to those after influenza vaccines and after all other vaccines using proportional reporting ratio (PRR) analysis by time. Results: There are 5137 cerebral thromboembolism AEs reported in the 3 years (36 months) after COVID-19 vaccines compared to 52 AEs for the influenza vaccines over the past 34 years (408 months) and 282 AEs for all other vaccines (excluding COVID-19) over the past 34 years (408 months). The PRR’s are significant when comparing AEs by time from COVID-19 vaccines to that of the influenza vaccines (p < 0.0001) or to that of all other vaccines (p < 0.0001). The CTE AEs PRR by time (95% confidence intervals) for the COVID-19 vaccine AEs vs influenza AEs is 1120 (95% confidence interval (723-1730), p < 0.0001) and for COVID-19 vaccines vs all others is 207 (95% confidence interval (144-296), p < 0.0001). Cerebral venous thromboembolism AEs are female predominant with a female/male odds ratio of 1.63 (95% confidence interval (1.52-1.74), p < 0.0001). Conversely, cerebral arterial thromboembolism has a nonsignificant male preponderance. Cerebral venous thromboembolism is far more common than cerebral arterial thromboembolism over 36 months with an odds ratio (OR) of 14.8 (95% confidence interval 14.0-15.5, p < 0.0001). Atrial fibrillation, the most common identifiable cause of cerebral arterial thromboembolism, occurs far more commonly after the COVID-19 as compared to all other vaccines with a PRR of 123 (95% CI 88.3-172, p < 0.0001) Conclusions: There is an alarming breach in the safety signal threshold concerning cerebral thrombosis AEs after COVID-19 vaccines compared to that of the influenza vaccines and even when compared to that of all other vaccines. An immediate global moratorium on the use of COVID-19 vaccines is necessary with an absolute contraindication in women of reproductive age.
Keywords
thrombosis; cerebral thromboembolism; Sars-CoV-2; COVID-19 vaccine; spike protein
Subject
Public Health and Healthcare, Primary Health Care
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The commenter has declared there is no conflict of interests.
Comment:
The article goes over well trodden ground of the VAERS passive, pharmaco-vigilance database. The number for the cerebral thrombosis AEs from the Pfizer and Moderna mRNA gene therapies are eye-watering. It beggars the imagination and credulity that such a clear and robust signal is so roundly ignored by FDA and CDC. The alarm was sounding very clearly in 2022 and nothing was done. This is a very well constructed statistical test and comparison with other vaccines in VAERS. This preprint, if it should be accepted for publication, is as much a scientific paper as it is evidence of malfeasance, treason and crimes against humanity.
The commenter has declared there is no conflict of interests.
Comment:
I would appreciate if the authors could comment on discrepancies between PRRs of this preprint and PRRs of an analysis done by the CDC: https://researchrebel.substack.com/p/cdc-finally-released-its-vaers-safety
The results differ quite dramatically (looking at 18+ excel tab):
Atrial fibrillation: 123 versus 2.82
Cerebral Venous Thrombosis: 2070/272 versus 5.13
Cerebral Thrombosis: 1120/207 versus 73.66
An error in the preprint? Date ranges matter? CDC fraud? Some kind of reporting lag? Something else?
Commenter:
The commenter has declared there is no conflict of interests.
Commenter:
The commenter has declared there is no conflict of interests.
https://researchrebel.substack.com/p/cdc-finally-released-its-vaers-safety The results differ quite dramatically (looking at 18+ excel tab):
Atrial fibrillation: 123 versus 2.82
Cerebral Venous Thrombosis: 2070/272 versus 5.13
Cerebral Thrombosis: 1120/207 versus 73.66
An error in the preprint? Date ranges matter? CDC fraud? Some kind of reporting lag? Something else?
Thank you.